主持国家自然基金面上项目2项、国家高技术研究发展计划(863计划)子课题、辽宁省重大科研项目2项,辽宁省“兴辽英才”特聘教授基金,教育厅重点科研项目,辽宁省自然科学基金、省医学高峰建设项目、教育厅基金多项,大连市科技局重点项目1项,科研课题总经费累计1000余万元。
专业文章以第一/通讯作者发表在Leukemia(白血病),Proceedings of the national academy of sciences (PNAS,美国科学院院报)等国际著名杂志,影响因子累计达100。
科研上主要从事血液恶性肿瘤发生及治疗的分子机制研究,研发以新融合基因为分子标志物的诊断和治疗方法,并获得多项新融合基因发明专利,科研成果发表于国际著名杂志。
近3年来以通讯作者发表的文章
1) Zhao Z, Huo Y, Du Y, et al. A neutrophil extracellular trap-related risk score predicts prognosis and characterizes the tumor microenvironment in multiple myeloma. Sci Rep. 2024;14(1):2264.
2) Zhang C, Hou Y, Yang Y, Zhang J, Zheng X, Yan J. Second haploidentical bone marrow transplantation with antithymocyte antibody-containing conditioning regimen for graft failure in eight patients with severe aplastic anemia. Sci Rep. 2024;14(1):2293.
3) Xia L, Liu JY, Yang MY, et al. Osimertinib Covalently Binds to CD34 and Eliminates Myeloid Leukemia Stem/Progenitor Cells. Cancer Res. 2024;84(3):479-492.
4) Wu Z, Liu X, Xie F, et al. Comprehensive pan-cancer analysis identifies the RNA-binding protein LRPPRC as a novel prognostic and immune biomarker. Life Sci. 2024;343:122527.
5) Li Q, Wang F, Zhang X, Liu S, Sun MZ, Yan J. The ETV6-MECOM fusion protein promotes EMT-related properties by repressing the transactivation activity of E-cadherin promoter in K562 leukemia cells. Biochem Biophys Rep. 2024;38:101667.
6) Zhang X, Hou Z, Huang D, et al. Single-cell heterogeneity and dynamic evolution of Ph-like acute lymphoblastic leukemia patient with novel TPR-PDGFRB fusion gene. Exp Hematol Oncol. 2023;12(1):19.
7) Yang LX, Zhang CT, Yang MY, et al. C1Q labels a highly aggressive macrophage-like leukemia population indicating extramedullary infiltration and relapse. Blood. 2023;141(7):766-786.
8) Du Y, Li C, Yan J. The efficacy and safety of venetoclax and azacytidine combination treatment in patients with acute myeloid leukemia and myelodysplastic syndrome: systematic review and meta-analysis. Hematology. 2023;28(1):2198098.
9) Zong X, Kang Z, Huang D, et al. One novel ACOT7-NPHP4 fusion gene identified in one patient with acute lymphoblastic leukemia: a case report. BMC Med Genomics. 2022;15(1):226.
10) Zhang X, Wang F, Yan F, et al. Identification of a novel HOOK3-FGFR1 fusion gene involved in activation of the NF-kappaB pathway. Cancer Cell Int. 2022;22(1):40.
11) Yan JS, Yang MY, Zhang XH, et al. Mitochondrial oxidative phosphorylation is dispensable for survival of CD34(+) chronic myeloid leukemia stem and progenitor cells. Cell Death Dis. 2022;13(4):384.
12) Wang R, Pan J, Han J, et al. Melatonin Attenuates Dasatinib-Aggravated Hypoxic Pulmonary Hypertension via Inhibiting Pulmonary Vascular Remodeling. Front Cardiovasc Med. 2022;9:790921.