谢冬医生简介

谢冬，上海市肺科医院胸外科行政副主任，主任医师，教授，博士生导师，博士后合作导师，IASLC （国际肺癌研究协会）会员，AME学术沙龙委员，EACTS（欧洲胸心血管外科学会）会员，ESTS（欧洲胸外科医师协会）会员，STS（美国胸外科医师协会）会员。2013-2014年至美国Mayo clinic（梅奥中心） 胸外科及癌症中心进修，个人年手术量1500余例，主要研究方向：基于临床大数据的肺癌精准治疗，肺癌人工智能相关研究，第一作者或通讯作者，在JTO，NC，EJC，JTCVS，ATS，Acta Pharmacol Sin,Acta Biomater等杂志发表SCI论文60余篇，国际会议发言10余次。擅长肺部磨玻璃结节，磨玻璃影，GGN，GGO，肺部结节以及早期肺癌的微创治疗，肺部结节（包括实性结节以及亚实性结节）的单孔微创外科治疗，并擅长肺癌、胸腺肿瘤（胸腺瘤，胸腺囊肿，胸腺癌）、纵隔肿瘤的综合治疗。

中国医促会加速康复外科学分会——胸外科康复学组副组长
中国胸心血管外科临床杂志青年编委
中国医促会胸外科分会青年委员
中国医师协会医学科普分会肿瘤科普专业委员会委员
中国医药教育协会肺癌医学教育委员会常委
中国医师协会上海市胸外科分会委员
CSCO微创肿瘤学分会委员
上海市医学会肿瘤靶分子委员会青年委员
JTO、JTD等杂志审稿专家
STS美国胸外科医师协会年会审稿专家

上海市浦江人才
上海市“医苑新星”杰出青年医学人才
获得上海市肺科医院“信赖的好医生”称号
2016年获同济大学十佳医务青年
2016年获上海市医务职工科技创新“星光计划”三等奖（第一完成人）
获得好大夫在线2016，2017，2019年，2020年度好大夫称号
2015年“不切除肺的支气管节段切除治疗支气管良恶性疾病”获上海市肺科医院 临床成果三等奖（第一完成人）
2015年“磨玻璃影早期肺癌的微创外科治疗”获上海市肺科医院 临床成果一等奖

主持国自然，市科委课题等十余项,个人获资助400余万
在国内外胸外科杂志发表论文160余篇，其中第一作者或通讯作者发表SCI论文60余篇，中华杂志30余篇。谷歌学术累计他引 3300 余次，H-index 为 32。主编《遇到磨玻璃结节莫惊慌》，《肺癌新辅助治疗进展》,《胸部肿瘤的精准治疗》,《肺移植新进展》四本专著，参编专著《肺外科学》、《Atlas of Uniportal VATS》、《肿瘤外科手术彩色图谱》等10本。
实用新型专利获得2项。
部分论文如下（第一作者或通讯作者）
1. Xie, D., Marks, R., Zhang, M., Jiang, G., Jatoi, A., Garces, Y. I., Mansfield, A., Molina, J. & Yang, P. (2015) Nomograms Predict Overall Survival for Patients with Small-Cell Lung Cancer Incorporating Pretreatment Peripheral Blood Markers, J Thorac Oncol. 10, 1213-20.
2. Chen, Y., Yuan, Z. C., Sun, W. Y., Shafiq, M., Zhu, J., Chen, J. F., Tang, H., Hu, L., Lin, W. K., Zeng, Y. X., Wang, L., Zhang, L., She, Y. L., Zheng, H., Zhao, G. F., Xie, D., Mo, X. M. & Chen, C. (2023) Vascular Endothelial Growth Factor-Recruiting Nanofiber Bandages Promote Multifunctional Skin Regeneration via Improved Angiogenesis and Immunomodulation, Advanced Fiber Materials. 5, 327-348.
3. Zhong, Y., Cai, C., Chen, T., Gui, H., Deng, J., Yang, M., Yu, B., Song, Y., Wang, T., Sun, X., Shi, J., Chen, Y., Xie, D., Chen, C. & She, Y. (2023) PET/CT based cross-modal deep learning signature to predict occult nodal metastasis in lung cancer, Nat Commun. 14, 7513.
4. Tao, C., Ren, Q., Qiu, P., Niu, S. N., Chen, Z. G., Li, K., Xie, D., Yu, N. & Wen, M. (2024) Design of multifunctional theranostic nanoplatforms with glutathione-triggered H2S 2 S generation and H2S-activitated 2 S-activitated multi-modal therapy, Chemical Engineering Journal. 495.
5. Li, K., Wu, L., Wang, H., Fu, Z., Gao, J., Liu, X., Fan, Y., Qin, X., Ni, D., Wang, J. & Xie, D. (2024) Apoptosis and cuproptosis Co-activated Copper-based metal-organic frameworks for cancer therapy, J Nanobiotechnology. 22, 546.
Zhong, Y., Cai, C., Chen, T., Gui, H., Chen, C., Deng, J., Yang, M., Yu, B., Song, Y., Wang, T., Chen, Y., Shi, H., 6.Xie, D., Chen, C. & She, Y. (2024) PET/CT-based deep learning grading signature to optimize surgical decisions for clinical stage I invasive lung adenocarcinoma and biologic basis under its prediction: a multicenter study, Eur J Nucl Med Mol Imaging. 51, 521-534.
7. She, Y., Li, S., Deng, J., Ren, Y., Zhao, M., Zhong, Y., He, Y., Chen, Q., Zhao, D., Zhu, Y., Hou, L., Wu, C., Xie, D. & Chen, C. (2022) Clinicopathologic characteristics and prognostic impact of atypical EGFR mutations in completely resected lung adenocarcinoma, Eur J Cancer. 177, 53-62.
8. Hao, B. B., Ma, K., Xu, J. Y., Fan, R. F., Zhao, W. S., Jia, X. L., Zhai, L. H., Lee, S., Xie, D. & Tan, M. J. (2024) Proteomics analysis of histone deacetylase inhibitor-resistant solid tumors reveals resistant signatures and potential drug combinations, Acta Pharmacol Sin. 45, 1305-1315.
9. Shi, Y., Li, C., Zhang, X., Peng, C., Sun, P., Zhang, Q., Wu, L., Ding, Y., Xie, D., Xu, Z. & Zhu, W. (2024) D3EGFR: a webserver for deep learning-guided drug sensitivity prediction and drug response information retrieval for EGFR mutation-driven lung cancer, Brief Bioinform. 25.
10. Lin, J. W., Zhou, Y., Xiao, H. P., Wu, L. L., Li, P. C., Huang, M. D., Xie, D., Xu, P., Li, X. X. & Li, Z. X. (2024) Antitumor effects of a Sb-rich polyoxometalate on non-small-cell lung cancer by inducing ferroptosis and apoptosis, Chemical Science.
11. Yang, M. L., Sun, W. Y., Wang, L., Tang, H., Xu, X., Yang, L. W., Ni, J. J., Zheng, K. E., Jiang, X., Xu, W. W., Zhao, G. F., She, Y. L., Zhang, L., Xie, D. & Chen, C. (2022) Curcumin loaded polycaprolactone scaffold capable of anti-inflammation to enhance tracheal cartilage regeneration, Materials & Design. 224.
12. Xie, D., Deng, J., Gonzalez-Rivas, D., Zhu, Y., Jiang, L., Jiang, G. & Chen, C. (2021) Comparison of video-assisted thoracoscopic surgery with thoracotomy in bronchial sleeve lobectomy for centrally located non-small cell lung cancer, J Thorac Cardiovasc Surg. 161, 403-413.e2.
13. Wu, L. L., Qiu, L. H., Chen, X., Yu, W. J., Li, C. W., Qian, J. Y., Liang, S. H., Lin, P., Long, H., Zhang, L. J., Li, Z. X., Li, K., Jiang, F., Ma, G. W. & Xie, D. (2023) Reconsidering N component of cancer staging for T1-2N0-2M0 small-cell lung cancer: a retrospective study based on multicenter cohort, Respir Res. 24, 168.
14. Qian, J. Y., Hao, Y., Yu, H. H., Wu, L. L., Liu, Z. Y., Peng, Q., Li, Z. X., Li, K., Liu, Y., Wang, R. R. & Xie, D. (2023) A Novel Systematic Oxidative Stress Score Predicts the Survival of Patients with Early-Stage Lung Adenocarcinoma, Cancers (Basel). 15.
15. Wu, L. L., Qian, J. Y., Li, C. W., Zhang, Y., Lin, W. K., Li, K., Li, Z. X. & Xie, D. (2022) The Clinical and Prognostic Characteristics of Primary Salivary Gland-Type Carcinoma in the Lung: A Population-Based Study, Cancers (Basel). 14.
16. Wu, L. L., Chen, W. T., Li, C. W., Song, S. H., Xu, S. Q., Wan, S. P., Liu, Z. Y., Lin, W. K., Li, K., Li, Z. X. & Xie, D. (2022) The Construction and Validation of Nomogram to Predict the Prognosis with Small-Cell Lung Cancer Followed Surgery, Cancers (Basel). 14.
17. Gao, J., Zhang, L., Li, Z., Wang, F., Qiu, L., Dou, X., Li, C., Zhu, Y., Ma, G., Jiang, G., Xie, D. & Chen, C. (2021) UniPortal thoracoscopic pneumonectomy does not compromise perioperative and long-term survival in patients with NSCLC: A retrospective, multicenter, and propensity score matching study, Lung Cancer. 159, 135-144.
18. Deng, J., Zhao, M., Wang, T., She, Y., Wu, J., E, H., Gao, J., Sun, X., Jiang, G., Zhu, Y., Xie, D. & Chen, C. (2020) A modified T categorization for part-solid lesions in Chinese patients with clinical stage I Non-small cell lung cancer, Lung Cancer. 145, 33-39.
19. Deng, J., She, Y., Yang, M., Zhang, L., Xie, D. & Chen, C. (2020) Radiomics: a potential biomarker for N2 malignancy in clinical stage I lung adenocarcinoma, Transl Lung Cancer Res. 9, 1623-1624.
20. Xie, D., Wang, T. T., Huang, S. J., Deng, J. J., Ren, Y. J., Yang, Y., Wu, J. Q., Zhang, L., Fei, K., Sun, X. W., She, Y. L. & Chen, C. (2020) Radiomics nomogram for prediction disease-free survival and adjuvant chemotherapy benefits in patients with resected stage I lung adenocarcinoma, Transl Lung Cancer Res. 9, 1112-1123.
21. Yang, M., She, Y., Deng, J., Wang, T., Ren, Y., Su, H., Wu, J., Sun, X., Jiang, G., Fei, K., Zhang, L., Xie, D. & Chen, C. (2019) CT-based radiomics signature for the stratification of N2 disease risk in clinical stage I lung adenocarcinoma, Transl Lung Cancer Res. 8, 876-885.
22.Shen Y, Yu N, Zhao W, Niu S, Qiu P, Zeng H, Chen Z, Men W, Xie D.M1-macrophage membrane-camouflaged nanoframeworks activate multiple immunity via calcium overload and photo-sonosensitization.Biomaterials,2025,DOI: 10.1016/j.biomaterials.2025.123287.
23.Lin W, Tang H, Cao R, Chen J, Wang L, She Y, Zhang L, Chen Y, Pan Z, Bai Q, Zhao D, Yang M, Zhao G, Sun W, Xie D, Chen C.3D-printed Engineered Trachea Functionalized by Diverse Extracellular Matrix Particles.Adv Healthc Mater,2025,DOI: 10.1002/adhm.202500124.
24.Yi C, Bian D, Wang J, Hu S, Sun L, Yan Y, Wang S, Shen Z, Yu H, Yang Y, Zhou Y, Liu X, Song N, Zhu Y, Zhao D, Jiang G, Duan L, He W, Xie D, Dai J, Zhang L, Zhang P.: Anti-PD1 based precision induction therapy in unresectable stage III non-small cell lung cancer: a phase II umbrella clinical trial. Nat Commun 2025, 16(1):1932.
25.Wen M, Qiu P, Meng J, Zhao W, Wang X, Niu S, Tao C, Yu N, Chen Z, Xie D: Multifunctional nanozymes for sonodynamic-enhanced immune checkpoint blockade therapy by inactivating PI3K/AKT signal pathway. Biomaterials 2025, 318:123125.
26.Zhou LQ, Li K, Liu YY, Zhang RJ, Yao YC, Chen QQ, Xie D, Zhang XJ: Living Cell-Derived Intelligent Nanobots for Precision Oncotherapy. Advanced Functional Materials 2024, 34(10).
27.Zhong Y, Cai C, Chen T, Gui H, Chen C, Deng J, Yang M, Yu B, Song Y, Wang T et al: PET/CT-based deep learning grading signature to optimize surgical decisions for clinical stage I invasive lung adenocarcinoma and biologic basis under its prediction: a multicenter study. Eur J Nucl Med Mol Imaging 2024, 51(2):521-534.
28.Lin JW, Zhou Y, Xiao HP, Wu LL, Li PC, Huang MD, Xie D, Xu P, Li XX, Li ZX: Antitumor effects of a Sb-rich polyoxometalate on non-small-cell lung cancer by inducing ferroptosis and apoptosis. Chem Sci 2024, 15(37):15367-15376.



部分中文文章：
1.谢冬,陈昶，王海峰，等. 闭合性气管支气管损伤15例. 中华胸心血管外科杂志,2016,32(2)94-98.
2. 包敏伟,谢冬,费苛，姜格宁，等. 116例胸腺囊肿的外科治疗. 中华胸心血管外科杂志,2016,32(1):14-17.
3. 谢冬, 包敏伟,谢惠康，等.113例纵隔畸胎瘤的外科治疗. 中华胸心血管外科杂志,2016，32(3)：132-135.
4. 周琪,谢冬,费苛,姜格宁. 心包切开术后综合征诊治进展.中国胸心血管外科临床杂志. 2017, 24(4): 306-309.
5.谢冬,陈昶,朱余明,姜格宁.单孔胸腔镜手术的现状与展望.中华腔镜外科杂志,2016,9(2):4-7.
6.谢冬,陈昶,姜格宁. 肺癌外科手术切口的演变与发展趋势,中国肺癌杂志, ,2016,(6):343-346.
7. 谢冬,戴洁,杨平,姜格宁.肺癌精准外科发展现状与展望, 中华实验外科杂志,2016,(8):1889-1892.
8. 厉逑元, 谢冬, 姜格宁.普胸外科手术风险预测模型的现状与进展,中华胸心血管外科杂志，2016,(9):561-564,568.
9.谢冬, 姜格宁. 胸锁关节感染的外科治疗，中华胸心血管外科杂志,2016,, 32(8):506-508.
10.谢冬,金宇星,王海峰等. 59例支气管结石病的外科治疗. 中华胸心血管外科杂志,2015,31(4):217-220.
11. 谢冬, 姜格宁，赵德平，等. 单孔全胸腔镜治疗中央型肺部肿瘤5例. 中华胸心血管外科杂志, 2015,31(3):177-178.
12.谢冬,尤小芳,谢惠康,陈晓峰,徐志飞,姜格宁, 陈昶,周晓,丁嘉安. 18例支气管内型错构瘤的临床分析. 中华胸心血管外科杂志,2012,28(3):167-168.
13. 谢冬,姜格宁,徐志飞等.插管后气管狭窄的外科治疗进展. 中华胸心血管外科杂志, 2013, 29(3):180-182.
14.谢冬,姜格宁,费苛,等. 肺切除术后支气管胸膜瘘的治疗进展. 中华胸心血管外科杂志, 2013, 29(8):502-504.
15.谢冬,姜格宁,陈晓峰，等.114例肺隔离症的外科治疗. 中华外科杂志, 2013，51(9):861-862.
16. 谢冬,费苛,姜格宁，等. 不切除肺的支气管节段切除术23例报道. 中华外科杂志, 2013，51(10):942-944.