刘凌波医生简介

医学博士， 留美博士后，三级教授，主任医师，博士研究生导师，武汉协和医院“协和名医-卓越医师”称号获得者。从1984年开始从事血液临床和医学研究，对各种血液病，特别是复发难治白血病的诊治积累了较丰富的经验,重视根据经验实施个体化与分子靶向治疗。主要研究方向：白血病干细胞干性维持与急性髓系白血病耐药复发的机制和对策。以主持人身份获 6 项国家自然科学基金项目，及多项国家重点实验室、省部和市校级项目资助。

附：华中科技大学同济医学院协和医院血液病研究所刘凌波课题组博士和硕士研究生招聘
1.要求：具有强烈的事业心，热爱科学研究，思维活跃，富有责任心，能吃苦耐劳，具有良好团队合作精神，良好的中英文表达能力。
2.特别欢迎有硕士和博士连读的有志青年报考。

目前主持的在研课题：国家自然科学基金项目2项。

研究生培养情况：
1.已培养毕业博士研究生：6人（均留本校血液科或其它相关部门工作,其中4人因表现优秀曾经被推荐到美国合作实验室进行过博士后研究）。
2.已培养毕业硕士研究生：6人（1人已获得美国Ph.D并在美国发展，其它均在国内三甲医院工作）。

研究生培养特色：
本人掌握领域前沿研究动态，根据本人在USA博士后工作经验进行培养，确保充分的时间与本组成员定期认真讨论，从选题、课题实施、论文写作与投稿进行全程具体指导。优秀者可直接推荐到美国合作实验室从事博士后研究。

美国血液病学会会员,中国生理学会血液学专业委员会 委员，湖北省医学生物免疫学会血液学专委会 急性髓系白血病分会 主任委员

近期发表的代表性论文：
1.Chen, Y., Wen, J., Li, Q. ...Lingbo Liu RAB27B-regulated exosomes mediate LSC maintenance via resistance to senescence and crosstalk with the microenvironment. Leukemia (2023). https://doi.org/10.1038/s41375-023-02097-3

2.Wen J, Chen Y, Liao C, ... Liu L.Engineered mesenchymal stem cell exosomes loaded with miR-34c-5p selectively promote eradication of acute myeloid leukemia stem cells.Cancer Lett. 2023 Oct 28:575:216407. doi: 10.1016/j.canlet.2023.216407. Epub 2023 Sep 26.

3.Niu J, Peng D, Liu L.Drug Resistance Mechanisms of Acute Myeloid Leukemia Stem Cells.Front Oncol. 2022 Jul 5;12:896426. doi: 10.3389/fonc.2022.896426.

4.Chenxi Liao,Yin Xiao,Lingbo Liu.The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence.Cancer Manag Res. 2020 Dec 31;12:13553-13566. doi: 10.2147/CMAR.S285083.

5.Li Xiaoyi，Ma Xiao，Chen Ying，Peng Danyue，Wang Huifang，Chen Suhua，Xiao Yin，Li Lei，Zhou Hao，Cheng Fanjun，Gao Yingdai，Chang Jiwei，Cheng Tao，Liu Lingbo. Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood CD34+ cells via inhibition of senescence. Stem Cells Translational Medicine. 2020 June, DOI: 10.1002/sctm.20-0129 .

6.Wang J, Li Y, Wang P, Han G, Zhang T, Chang J, Yin R, Shan Y, Wen J, Xie X, Feng M, Wang Q, Hu J, Cheng Y, Zhang T, Li Y, Gao Z, Guo C, Wang J, Liang J, Cui M, Gao K, Chai J, Liu W, Cheng H, Li L, Zhou F, Liu L, Luo Y, Li S, Zhang H. Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis.Cell Stem Cell. 2020 May 8:S1934-5909(20)30140-5. doi: 10.1016/j.stem.2020.04.001.

7.Danyue Peng*, Huifang Wang*, Lei Li*, Xiao Ma, Ying Chen, Hao Zhou1, Yi Luo＃, Yin Xiao＃, and Lingbo Liu＃.miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding.Leukemia. 2018 May;32(5):1180-1188. doi: 10.1038/s41375-018-0015-2. Epub 2018 Feb 2.

8.Shao L, Feng W, Li H, Gardner D, Luo Y, Wang Y, Liu L, Meng A, Sharpless NE, Zhou D.Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner.Blood. 2014 May 15;123(20):3105-15.

9.Luo Y, Li L, Zou P, Wang J, Shao L, Zhou D, Liu L.Rapamycin Enhances Long-Term Hematopoietic Reconstitution of Ex Vivo Expanded Mouse Hematopoietic Stem Cells by Inhibiting Senescence.Transplantation. 2013 2014 Jan 15;97(1):20-9.

10.Yin Xiao, Jie Wang, Hui Song, Ping Zou, Daohong Zhou，Lingbo Liu. CD34+ cells from patients with myelodysplastic syndrome present different p21 dependent premature senescence.Leukemia Research 37 (2013) 333– 340

11.Jing Zou, Ping Zou, Jie Wang, Lei Li , Yong Wang , Daohong Zhou and Lingbo Liu. Inhibition of p38 MAPK Activity Promotes ex vivo Expansion of Human Cord Blood Hematopoietic Stem Cells. Annals of Hematology; (2012) 91:813–823 。

12.Luo Y, Zou P, Zou J, Wang J, Zhou D, Liu L. Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKα dependent manner. Exp Gerontol.，Epub 2011 Jul 23.46(11):860-7. 2011 Nov.

13. Wang Y, Liu L, Pazhanisamy SK, Li H, Meng A, Zhou D. Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells. Free Radical Biology & Medicine, January 2010，48:348-356.

14.Wang Y, Liu L, Zhou D. Inhibition of p38 MAPK Attenuates Ionizing Radiation-Induced Hematopoietic Cell Senescence and Residual Bone Marrow Injury. Radiat Res. 2011 Dec;176(6):743-52. Epub 2011 Oct 20.

15.Wang Y, Kellner J, Liu L, Zhou D. Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion.Stem Cells Dev. 2011 Ju