发表论文60篇,其中以第一作者或通讯作者在《Nature Communications》、《Cancer Research》、《Head Neck》、《Laryngoscope》、《Oral Oncology》和《Eur Radiol》等期刊发表论文40篇,其中:1篇被国际权威甲状腺组织ATA的相关指南引用,1篇被SEOM-GETNE-TTCC甲状腺指南引用,1篇被欧洲(ESES)甲状腺指南引用,2篇被JCO Global Oncology的2024 LACTHNC和欧洲REFCOR的头颈肿瘤指南/共识引用,另外以第二作者在《Journal of Clinical Investigation》发表论著。
主持国家自然基金、省部级等科研课题10余项,参与国家级和省部级科研课题多项。
参编专业书籍《头颈外科临床实践与技巧》(2020)、《肿瘤靶向治疗和免疫治疗进展》(2020,甲状腺癌)、《中华耳鼻咽喉头颈外科学》头颈外科分册、《头颈部肿瘤:基础与临床的转化》(2020,甲状腺癌)等。
科研项目:
[1] 2019 国家自然基金 81972896,主持;
[2] 2019 国家重点实验室课题 (华南肿瘤学国家重点实验室) HN2019-09,主持;
[3] 2019 广东省自然基金,主持;
[4] 2015 广东省自然基金 2015A030313058,主持;
[5] 2013 国家自然基金 81302368,主持;
[6] 2012广东省科技计划项目基金,主持;
[7] 2010 广东省卫生厅基金,主持;
[8] TSHR调控人甲状腺癌细胞增殖和转移能力的机制及其潜在临床意义 2012 国家自然基金 81272955,第二负责人;
[9] 以TSHR通路为主的分化型甲状腺癌个体化内分泌治疗的研究 广东省自然科学基金,第二负责人;
[10] 同族基因Satb1和Satb2在喉癌细胞增殖中的拮抗作用研究 2010广东省科技计划项目,第二负责人;
[11] 抑制VEGF-C 基因联合应用ACEI 药物对口腔鳞癌淋巴转移影响的实验研究 2009广东省科技计划项目,第二负责人;
[12] 下咽癌及颈段食管癌术后缺损功能性修复方法的研究 2006年广东省科技计划项目,第三负责人;
[13] 甲状腺乳头状癌相关分子标志物的研究 2009年广东省自然科学基金,第五负责人;
[14] 甲状腺乳头状癌转移过程中的淋巴内皮表型转变 2023年中山大学医学院大学生创新训练项目,主持;
[15] 探索衰老相关FAP+癌成纤维细胞在Braf突变在甲状腺乳头癌失分化中的作用机制 2023年中山大学医学院大学生创新训练项目,主持;
[16] 2023年广东省新医学教育改革项目,主持;
[17] 基于成纤维细胞活化蛋白(FAP)显像的甲状腺癌失分化进程动态评估 中山大学医学院大学生创新训练项目,主持;
[18] 通过靶向FAP PET显像评估MAPK通路抑制对甲状腺癌失分化及FAP表达的影响 中山大学医学院大学生创新训练项目,主持;
[19] 基于机器学习算法的甲状腺乳头状癌复发的诊断及预后风险模型 2024年中山大学医学院大学生创新训练项目,主持;
代表性文章(临床总结和部分研究):
[1] Zhuang SM, Xie LE, Pang F, Zhong QY, Sun XM, Wen WP, Liu TR(通讯作者). Role of primary tumor resection in patients with metastatic medullary thyroid cancer who have unresectable distant metastases. Head Neck. 2021;43(11): 3386-3392.
[2] Liu T(第一作者), Su X, Chen W, et al. A mathematical model using computed tomography for the diagnosis of metastatic central compartment lymph nodes in papillary thyroid carcinoma. Eur Radiol. 2014; 24(11):2827-2834.
[3] Liu T(第一作者), Xiao Z, Zhuang S, et al. Surgical Management of Secondary Hyperparathyroidism (继发性甲状旁腺功能亢进的外科治疗). HPBS. 2016; 2(4): 52-57.
[4] Liu TR(第一作者), Xiao ZW, Xu HN, et al. Treatment and prognosis of anaplastic thyroid carcinoma: a clinical study of 50 cases. PLoS One. 2016; 11(10):e0164840.
[5] Liu TR(第一作者), Su X, Qiu WS, et al. Thyroid-stimulating hormone receptor affects metastasis and prognosis in papillary thyroid carcinoma. Eur Rev Med Pharmacol Sci. 2016; 20(17):3582-3591.
[6] Liu T(第一作者), Men Q, Su X, et al. Downregulated expression of TSHR is associated with distant metastasis in thyroid cancer. Oncol Lett, 2017; 14(6): 7506-7512.
[7] Sun XM, Pang F, Zhuang SM, Xie LE, Zhong QY, Liu TR(通讯作者). Tumor size rather than the thyroid invasion affects the prognosis of parathyroid carcinoma without lymph node or distant metastasis. Eur Arch Otorhinolaryngol. Eur Arch Otorhinolaryngol. 2022;279(9):4587-4594.
[8] 刘天润(第一作者),等.侵袭性分化型甲状腺癌的治疗及预后分析.中华普通外科杂志. 2010; 25(8):616-620.
[9] Liu TR(第一作者), Xu LH, Yang AK, et al. Decreased Expression of SATB2: a Novel Independent Prognostic Marker of Worse Outcome in Laryngeal Carcinoma Patients. PLoS One. 2012; 7(7):e40704.
[10] Ouyang D, Liu TR (共同第一), Liu XW, et al. Combined hyoid bone flap in laryngeal reconstruction after extensive partial laryngectomy for laryngeal cancer. Eur Arch Otorhinolaryngol. 2013, 270(4):1455-1462.
[11] Li ZQ, Zou L, Liu TR (共同第一), et al. Prognostic value of body mass index before treatment for laryngeal squamous cell carcinoma. Cancer Biol Med. 2015; 12(4):394-400.
[12] Ding W#, Liu T#(共同第一), ......, Yang A. Supraglottic squamous cell carcinomas have distinctive clinical features and prognosis based on subregion. PLoS One. 2017; 20; 12(11):e0188322.
[13] Ouyang D, Liu TR, Chen YF, et al. Modified frontolateral partial laryngectomy operation: combined muscle-pedicle hyoid bone and thyrohyoid membrane flap in laryngeal reconstruction. Cancer Biol Med. 2013, 10(2):103-109.
[14] Xie C, Liao J, Huang C, Wei F, Liu T, Wen W, Sun W. Basaloid squamous cell carcinoma of the hypopharynx: an analysis of 213 cases. Eur Arch Otorhinolaryngol. 2021, Jul 28. doi: 10.1007/s00405-021-07007-w.
[15] 刘天润(第一作者),等. 221例晚期喉鳞癌患者术后的生存和预后分析. 癌症. 2009; 28(3): 297-302. (in Chinese and English)
[16] Liu TR(第一作者), Chen FJ, Yang AK, et al. Elective neck dissection in clinical stage I squamous cell carcinoma of the tongue: Does it improve regional control or survival time? Oral Oncol. 2011; 47(2):136-141.
[17] Fu X, Chen S, Chen W, Yang Z, Song M, Li H, Zhang H, Yao F, Su X, Liu T(共同通讯作者), Yang AK. Clinical analysis of second primary gingival squamous cell carcinoma after radiotherapy. Oral Oncol. 2018(9); 84:20-24.
[18] Zou L, Liu TR (共同第一), Yang AK. Metabolic syndrome is associated with better prognosis in patients with tongue squamous cell carcinoma. Chin J Cancer. 2015; 34(4):184-188.
[19] Liu T(第一作者), Xie L, ……, Zhang G. Discrepancy between cTNM stage and postoperative pTNM stage of oral squamous cell carcinoma. J Med Discov. 2017; 2(3):jmd17031; DOI:10.24262/jmd.2.3.17031.
[20] Liu TR(第一作者), Wang W, Zhuang SM, et al. A clinical analysis of retropharyngeal lymph node metastasis from oral tongue carcinoma. J Med Discov. 2017; 2(4):jmd17047.
[21] Zhang X#, Liu T# (共同第一), … …, Song M. Impacts of Oral Reconstruction on Patients with Tongue Squamous Cell Carcinoma. J Med Discov. 2017; 2(4):jmd17041.
[22] Wang YH, Wu MW, ..., Liu TR, ..., Yang AK, et al. COX-2 Gene increases tongue cancer cell proliferation and invasion through VEGF-C pathway. Med Oncol. 2011; 28(S1): S360-366.
[23] 刘天润(第一作者),等. 颈清扫术在临床Ⅰ期舌鳞状细胞癌患者中的疗效评价. 中华耳鼻咽喉头颈外科杂志. 2006; 41(1): 38-42.
[24] 杨安奎,刘天润,等. 229例晚期舌鳞癌患者的生存和预后分析. 癌症. 2008; 27(12): 1315-1320. (in Chinese and English)
[25] 杨安奎,刘天润,等. 舌鳞癌患者术前颈部淋巴结分期价值的探讨. 中华肿瘤防治杂志. 2008; 15(20):1578-1583.
[26] Liu TR(第一作者), Chen FJ, Qian CN, et al. Primary salivary gland type nasopharyngeal carcinoma: Therapeutic outcomes and prognostic factors. Head Neck. 2010; 32(4): 435-444.
[27] Liu TR(第一作者), Yang AK, Guo X, et al. Adenoid cystic carcinoma of the nasopharynx: 27-year experience. Laryngoscope. 2008; 118(11):1981-1988.
[28] Liu TR(第一作者), Chen FJ, Zhang GP, et al. Different therapeutic strategies in nasopharyngeal salivary glands type carcinomas. Curr Opin Otolaryngol Head Neck Surg. 2011; 19(2): 87-91.
[29] Ding W, Xie L, Liang J, Li Z, Hu T, Chen X, Zhang T, Liu T (通讯作者). Pattern and prognostic value of lymph node metastasis in sinonasal mucosal melanoma. Ear Nose Throat J. 2022 Jul 5:1455613221112350. doi: 10.1177/01455613221112350. Online ahead of print.
[30] 刘天润(第一作者), 等. 上颌窦腺样囊性癌36例临床分析.中华耳鼻咽喉头颈外科杂志. 2008; 43(1):37-40.
[31] 杨安奎, 刘天润, 等.同步放化疗与单纯放疗在晚期鼻咽癌中疗效比较的Meta分析.中华耳鼻咽喉头颈外科杂志. 2008; 43(3):218-223.
[32] 丁卫泉, 杨安奎, 欧阳电, 刘天润, 袁步奇, 彭蓉蓉. 外耳道癌12例临床分析. 实用医学杂志. 2011; 27(8) : 1440-1442.
[33] Liu T (第一作者), Ma W, Xu H, Huang M, Zhang D, He Z, Zhang L, Brem S, O'Rourke DM, Gong Y, Mou Y, Zhang Z, Fan Y. PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma. Nat Commun. 2018; 9(1): 3439.
[34] Liu T (第一作者), Xu H, Huang M, Ma W, Saxena D, Lustig RA, Alonso-Basanta M, Zhang Z, O Rourke DM, Zhang L, Gong Y, Kao GD, Dorsey JF, Fan Y. Circulating glioma cells exhibit stem cell-like properties. Cancer Res. 2018; 78(23):6632-6642.
[35] Huang M, Liu T(第二作者), Ma P, et al. c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma. J Clin Invest. 2016; 126(5): 1801-1814.
[36] Xiao J, Mu J, Liu T, Xu H. Dig the root of cancer: targeting cancer stem cells therapy. J Med Discov, 2017; 2(2): jmd17003.
[37] Wang Y, Xu H, Liu T,......, Fan Y. Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells. JCI Insight. 2018; 3(3). pii: 98096.
[38] Wang Q, He Z, Huang M, Liu T, ......, Fan Y. Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α. Nat Commun. 2018;9(1):559.
[39] Lin Y, Gao W, Yue H, Chen W, Liu T, Ye J, Cai Q, Ye F, He L, Xie X, Xiong G, Wang B, Pang F, Li P, Wu J, Wang B, Huang J, Wen W, Lei W. A novel risk score for the prediction of airway management in patients with deep neck space abscess: a multicenter retrospective cohort study. J Intensive Care. 2021;9(1):41. doi: 10.1186/s40560-021-00554-8.
[40] Chen L, L Z i, Zheng Y, Zhou F, Zhao J, Zhai Q, Zhang Z, Liu T, Chen Y, Qi S. 3D-printed dermis-specific extracellular matrix mitigates scar contraction via inducing early angiogenesis and macrophage M2 polarization. Bioactive Materials. Available online 22 September 2021. https://doi.org/10.1016/j.bioactmat.2021.09.008.
[41] Li HX, Liu TR, Tu ZX, Xie CB, Wen WP, Sun W. Screening of Tumor Antigens and Construction of Immune Subtypes for mRNA Vaccine Development in Head and Neck Squamous Cell Carcinoma. Biomolecules. 2022 31;13(1):90.
[42] Chen K, Li X, Dong S, Guo Y, Luo Z, Zhuang SM, Liu J, Liu T(共同通讯), Liao J, Wen W. Modulating tumor-associated macrophages through CSF1R inhibition: a potential therapeutic strategy for HNSCC. J Transl Med. 2025 8;23(1):27.
[43] Pang F, Guo Y, Liu TR(通讯作者). Surgical treatment of nasopharyngeal carcinoma. Mini-invasive Surg. 2024;8:27.
... ... ... ...