将放射性粒子微创内照射技术引入中国，并通过CT引导和3D打印技术实现人体各部位的精准植入，实现穿刺快捷，微创，为大量无法手术，复发，转移患者带来了新的希望！
主要科研成果，按发表时间顺序排列（2016-2021）：
1: Li C, Xu X, Wei S, Jiang P, Xue L, Wang J; Senior Correspondence. Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer. J Immunother Cancer. 2021 Jan;9(1):e001341. doi: 10.1136/jitc-2020-001341. PMID: 33504575.
2: Jiang, Y., Zhen, P., Dai, J., Li, Y., Liu, S., Xu, J., Wang, J. (2021). Long-Term Safety and Efficacy of CT-Guided I(125) Radioactive Seed Implantation as a Salvage Therapy for Recurrent Head and Neck Squamous Carcinoma: A Multicenter Retrospective Study. Front Oncol, 11, 645077. doi:10.3389/fonc.2021.645077. PMID: 34277401; PMCID: PMC8281320
3: Jiang W, Chen Y, Ji Z, Jiang Y, Qiu B, Sun H, Wang J. The accuracy and dosimetric analysis of 3D-printing non-coplanar template-assisted iodine-125 seed implantation for recurrent chest wall cancer. J Contemp Brachytherapy. 2021 Jun;13(3):273-279. doi: 10.5114/jcb.2021.106250. Epub 2021 May 18. PMID: 34122566; PMCID: PMC8170518.
4: Xue H, Qiu B, Wang H, Jiang P, Sukocheva O, Fan R, Xue L, Wang J. Stereotactic Ablative Brachytherapy: Recent Advances in Optimization of Radiobiological Cancer Therapy. Cancers (Basel). 2021 Jul 12;13(14):3493. doi: 10.3390/cancers13143493. PMID: 34298703; PMCID: PMC8304109.
5: Wang L, Wang H, Jiang Y, Ji Z, Guo F, Jiang P, Qiu B, Sun H, Fan J, Li W, Wang J. Dosimetric comparison of computed tomography-guided iodine-125 seed implantation assisted with and without three-dimensional printing non-coplanar template in locally recurrent rectal cancer: a propensity score matching study. J Contemp Brachytherapy. 2021 Feb;13(1):18-23. doi: 10.5114/jcb.2021.103582. Epub 2021 Feb 18. PMID: 34025732; PMCID: PMC8117706.
6: Yuan ZH, Liu T, Wang H, Xue LX, Wang JJ. Fatty Acids Metabolism: The Bridge Between Ferroptosis and Ionizing Radiation. Front Cell Dev Biol. 2021 Jun 24;9:675617. doi: 10.3389/fcell.2021.675617. PMID: 34249928; PMCID: PMC8264768.
7: Qiu B, Jiang Y, Ji Z, Sun H, Fan J, Li W, Shao Y, Jiang P, Wang J. The Accuracy of Individualized 3D-Printing Template-Assisted I125 Radioactive Seed Implantation for Recurrent/Metastatic Head and Neck Cancer. Front Oncol. 2021 Mar 31;11:664996. doi: 10.3389/fonc.2021.664996. PMID: 33869069; PMCID: PMC8045752.
8: Wang H, Peng R, Li X, Wang Y, Jiang Y, Ji Z, Guo F, Tian S, Sun H, Fan J, Wang J. The dosimetry evaluation of 3D printing non-coplanar template-assisted CT-guided 125I seed stereotactic ablation brachytherapy for pelvic recurrent rectal cancer after external beam radiotherapy. J Radiat Res. 2021 May 12;62(3):473-482. doi: 10.1093/jrr/rraa144. PMID: 33616168; PMCID: PMC8127672.
9: Qiu B, Jiang P, Ji Z, Huo X, Sun H, Wang J. Brachytherapy for lung cancer. Brachytherapy. 2021 Mar-Apr;20(2):454-466. doi: 10.1016/j.brachy.2020.11.009. Epub 2020 Dec 24. PMID: 33358847.
10: Liu Y, Jiang P, Zhang H, Wang J. Safety and efficacy of 3D-printed templates assisted CT-guided radioactive iodine-125 seed implantation for the treatment of recurrent cervical carcinoma after external beam radiotherapy. J Gynecol Oncol. 2021 Mar;32(2):e15. doi: 10.3802/jgo.2021.32.e15. Epub 2020 Nov 25. PMID: 33300313; PMCID: PMC7930458.
11: Jiang W, Jiang P, Wei S, Jiang Y, Ji Z, Sun H, Fan J, Li W, Shao Y, Wang J. The accuracy and safety of CT-guided iodine-125 seed implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma. World J Surg Oncol. 2020 Nov 25;18(1):307. doi: 10.1186/s12957-020-02087-0. PMID: 33239023; PMCID: PMC7690097.
12: Wei S, Wang J. How to manage tumour radiotherapy during COVID-19 pandemic?
Eur J Cancer Care (Engl). 2020 Sep;29(5):e13288. doi: 10.1111/ecc.13288. PMID: 32991057; PMCID: PMC7536973.
13: Wang L, Wang H, Jiang Y, Ji Z, Guo F, Jiang P, Li X, Chen Y, Sun H, Fan J, Li W, Li X, Wang J. The efficacy and dosimetry analysis of CT-guided 125I seed implantation assisted with 3D-printing non-co-planar template in locally recurrent rectal cancer. Radiat Oncol. 2020 Jul 25;15(1):179. doi: 10.1186/s13014-020-01607-2. PMID: 32711542; PMCID: PMC7382046.
14: Li C, Jiang P, Wei S, Xu X, Wang J. Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects. Mol Cancer. 2020 Jul 17;19(1):116. doi: 10.1186/s12943-020-01234-1. PMID: 32680511; PMCID: PMC7367382.
15: Wang H, Li X, Peng R, Wang Y, Wang J. Stereotactic ablative radiotherapy for colorectal cancer liver metastasis. Semin Cancer Biol. 2021 Jun;71:21-32. doi: 10.1016/j.semcancer.2020.06.018. Epub 2020 Jul 3. PMID: 32629077.
16: Gong Y, Yang J, Wang Y, Xue L, Wang J. Metabolic factors contribute to T-cell inhibition in the ovarian cancer ascites. Int J Cancer. 2020 Oct 1;147(7):1768-1777. doi: 10.1002/ijc.32990. Epub 2020 Apr 25. PMID: 32208517; PMCID: PMC7496064.
17: Jiang P, Zhang X, Jiang W, Meng N, Aili A, Wang J. Analysis of long-term outcome of image-guided volumetric modulated arc therapy (VMAT) for primary malignant tumor of the cervical spine. Cancer Biol Ther. 2020 Jul 2;21(7):623-628. doi: 10.1080/15384047.2020.1743149. Epub 2020 Apr 16. PMID: 32298199; PMCID: PMC7515497.
18: Chen Y, Jiang Y, Ji Z, Jiang P, Xu F, Zhang Y, Zhang P, Guo F, Li X, Sun H, Lei R, Fan J, Li W, Huang Y, Wang J. Dosimetry, efficacy, and safety of three-dimensional printing noncoplanar template-assisted and CT-guided 125Iseed implantation for recurrent retroperitoneal lymphatic metastasis afterexternal beam radiotherapy. Brachytherapy. 2020 May-Jun;19(3):380-388. doi:10.1016/j.brachy.2020.02.009. Epub 2020 Apr 2. PMID: 32249183.
19: Chen Y, Zhuang H, Wang J. The rationale and toxicity of combined cranial radiotherapy and immune checkpoint inhibitors in non-small cell lung cancer. Asia Pac J Clin Oncol. 2020 Mar 4. doi: 10.1111/ajco.13327. Epub ahead of print. PMID: 32129944.
20: Wang H, Wang L, Jiang Y, Ji Z, Guo F, Jiang P, Li X, Chen Y, Sun H, Fan J, Du G, Wang J. Long-Term Outcomes and Prognostic Analysis of Computed Tomography-Guided Radioactive 125I Seed Implantation for Locally Recurrent Rectal Cancer After External Beam Radiotherapy or Surgery. Front Oncol. 2021 Jan 21;10:540096. doi: 10.3389/fonc.2020.540096. PMID: 33552943; PMCID: PMC7859443.
21: Qiu B, Aili A, Xue L, Jiang P, Wang J. Advances in Radiobiology of Stereotactic Ablative Radiotherapy. Front Oncol. 2020 Aug 7;10:1165. doi: 10.3389/fonc.2020.01165. PMID: 32850333; PMCID: PMC7426361.
22: Wen J, Xiong K, Aili A, Wang H, Zhu Y, Yu Z, Yao X, Jiang P, Xue L, Wang J. PEX5, a novel target of microRNA-31-5p, increases radioresistance in hepatocellular carcinoma by activating Wnt/β-catenin signaling and homologous recombination. Theranostics. 2020 Apr 6;10(12):5322-5340. doi: 10.7150/thno.42371. PMID: 32373215; PMCID: PMC7196300.
23: Qiu YY, Zhang KX, Ye X, Zhang XS, Xing C, Wu QS, Hu MM, Li PX, Wang JJ. Combination of Microwave Ablation and Percutaneous Osteoplasty for Treatment of Painful Extraspinal Bone Metastasis. J Vasc Interv Radiol. 2019 Dec;30(12):1934-1940. doi: 10.1016/j.jvir.2019.08.008. Epub 2019 Oct 24. PMID: 31669085.
24: Chen Y, Jiang Y, Ji Z, Jiang P, Xu F, Zhang Y, Guo F, Peng R, Li X, Sun H, Lei R, Fan J, Li W, Wang J. Efficacy and safety of CT-guided 125I seed implantation as a salvage treatment for locally recurrent head and neck soft tissue sarcoma after surgery and external beam radiotherapy: A 12-year study at a single institution. Brachytherapy. 2020 Jan-Feb;19(1):81-89. doi: 10.1016/j.brachy.2019.09.006. Epub 2019 Oct 22. PMID: 31653566.
25: Ji Z, Jiang Y, Guo F, Peng R, Sun H, Fan J, Xu F, Wang J. Safety and efficacy of CT-guided radioactive iodine-125 seed implantation assisted by a 3D printing template for the treatment of thoracic malignancies. J Cancer Res Clin Oncol. 2020 Jan;146(1):229-236. doi: 10.1007/s00432-019-03050-7. Epub 2019 Oct 19. PMID: 31630263.
26: Ji Z, Jiang Y, Guo F, Peng R, Sun H, Wang P, Fan J, Wang J. Radiation-related Adverse Effects of CT-guided Implantation of 125I Seeds for Thoracic Recurrent and/or Metastatic Malignancy. Sci Rep. 2019 Oct 15;9(1):14803. doi: 10.1038/s41598-019-51458-5. PMID: 31616052; PMCID: PMC6794248.
27: Li C, Wei S, Xu X, Jiang Y, Xue L, Jiang P, Wang J. Sorafenib attenuated the function of natural killer cells infiltrated in HCC through inhibiting ERK1/2. Int Immunopharmacol. 2019 Nov;76:105855. doi: 10.1016/j.intimp.2019.105855. Epub2019 Aug 28. PMID: 31472321.
28: Ji Z, Sun H, Jiang Y, Guo F, Peng R, Fan J, Wang J. Comparative study for CT-guided 125I seed implantation assisted by 3D printing coplanar and non-coplanar template in peripheral lung cancer. J Contemp Brachytherapy. 2019 Apr;11(2):169-173. doi: 10.5114/jcb.2019.84503. Epub 2019 Apr 29. PMID: 31139226; PMCID: PMC6536142.
29: Qu A, Jiang P, Sun H, Jiang W, Jiang Y, Tian S, Wang J. Efficacy and dosimetry analysis of image-guided radioactive 12I seed implantation as salvage treatment for pelvic recurrent cervical cancer after external beam radiotherapy. J Gynecol Oncol. 2019 Jan;30(1):e9. doi: 10.3802/jgo.2019.30.e9. Epub 2018 Oct 30. PMID: 30479093; PMCID: PMC6304405.
30: Jiang P, Wang J, Ran W, Jiang Y, Tian S, Sun H. Five-year outcome of ultrasound-guided interstitial permanent 125I seeds implantation for local head and neck recurrent tumors: a single center retrospective study. J Contemp Brachytherapy. 2019 Feb;11(1):28-34. doi: 10.5114/jcb.2019.83336. Epub 2019 Feb 28. PMID: 30911307; PMCID: PMC6431107.
31: Zhang S, Yang R, Shi C, Li J, Zhuang H, Tian S, Wang J. Noncoplanar VMAT for Brain Metastases: A Plan Quality and Delivery Efficiency Comparison With Coplanar VMAT, IMRT, and CyberKnife. Technol Cancer Res Treat. 2019 Jan 1;18:1533033819871621. doi: 10.1177/1533033819871621. PMID: 31451059; PMCID: PMC6710677.
32: Ji Z, Jiang Y, Tian S, Guo F, Peng R, Xu F, Sun H, Fan J, Wang J. The Effectiveness and Prognostic Factors of CT-Guided Radioactive I-125 Seed Implantation for the Treatment of Recurrent Head and Neck Cancer After External Beam Radiation Therapy. Int J Radiat Oncol Biol Phys. 2019 Mar 1;103(3):638-645. doi: 10.1016/j.ijrobp.2018.10.034. Epub 2018 Nov 2. PMID: 30391521.
33: Jiang Y, Ji Z, Guo F, Peng R, Sun H, Fan J, Wei S, Li W, Liu K, Lei J, Wang J. Side effects of CT-guided implantation of 125I seeds for recurrent malignant tumors of the head and neck assisted by 3D printing non co-planar template. Radiat Oncol. 2018 Feb 3;13(1):18. doi: 10.1186/s13014-018-0959-4. PMID: 29394937; PMCID: PMC5797361.
34: Pan Y, Yang R, Li J, Zhang X, Liu L, Wang J. Film-based dose validation of Monte Carlo algorithm for Cyberknife system with a CIRS thorax phantom. J Appl Clin Med Phys. 2018 May;19(3):142-148. doi: 10.1002/acm2.12314. Epub 2018 Mar 30. PMID: 29603564; PMCID: PMC5978558.
35: Wang J, Chai S, Zheng G, Jiang Y, Ji Z, Guo F, Zhuang H, Zhang K. Expert consensus statement on computed tomography-guided 125I radioactive seeds permanent interstitial brachytherapy. J Cancer Res Ther. 2018 Jan;14(1):12-17. doi: 10.4103/jcrt.JCRT_888_17. PMID: 29516952.
36: Ji Z, Wang G, Chen B, Zhang Y, Zhang L, Gao F, Chai S, Huo B, Zheng G, Huo X, Wang B, Zhu X, Meng D, Liu L, Zhu R, Han M, Zhang Y, Zhang K, Wang J. Clinical application of planar puncture template-assisted computed tomography-guided percutaneous biopsy for small pulmonary nodules. J Cancer Res Ther. 2018;14(7):1632-1637. doi: 10.4103/jcrt.JCRT_1017_17. PMID: 30589051.
37: Wei S, Li C, Yin Z, Wen J, Meng H, Xue L, Wang J. Histone methylation in DNA repair and clinical practice: new findings during the past 5-years. J Cancer. 2018 May 24;9(12):2072-2081. doi: 10.7150/jca.23427. PMID: 29937925; PMCID: PMC6010677.
38: Wang J, Zhang F, Guo J, Chai S, Zheng G, Zhang K, Liao A, Jiang P, Jiang Y, Ji Z. Expert consensus workshop report: Guideline for three-dimensional printing template-assisted computed tomography-guided 125I seeds interstitial implantation brachytherapy. J Cancer Res Ther. 2017;13(4):607-612. doi: 10.4103/jcrt.JCRT_412_17. PMID: 28901301.
39: Yao LH, Su L, Liu L, Sun HT, Wang JJ. Stenting of the Portal Vein Combined with Different Numbers of Iodine-125 Seed Strands: Dosimetric Analyses. Chin Med J (Engl). 2017 Sep 20;130(18):2183-2189. doi: 10.4103/0366-6999.213974. PMID: 28875954; PMCID: PMC5598330.
40: Ji Z, Jiang Y, Su L, Guo F, Peng R, Sun H, Fan J, Wang J. Dosimetry Verification of 125I Seeds Implantation With Three-Dimensional Printing Noncoplanar Templates and CT Guidance for Paravertebral/Retroperitoneal Malignant Tumors. Technol Cancer Res Treat. 2017 Dec;16(6):1044-1050. doi: 10.1177/1533034617723221. Epub 2017 Aug 7. PMID: 28782439; PMCID: PMC5762069.
41: Ji Z, Jiang Y, Guo F, Sun H, Fan J, Zhang L, Wang J. Dosimetry verification of radioactive seed implantation for malignant tumors assisted by 3D printing individual templates and CT guidance. Appl Radiat Isot. 2017 Jun;124:68-74. doi: 10.1016/j.apradiso.2016.12.009. Epub 2016 Dec 8. PMID: 28342381.
42: Hu L, Wang H, Huang L, Zhao Y, Wang J. Crosstalk between autophagy and intracellular radiation response (Review). Int J Oncol. 2016 Dec;49(6):2217-2226. doi: 10.3892/ijo.2016.3719. Epub 2016 Oct 5. PMID: 27748893.
43: Pan Y, Yang R, Zhang S, Li J, Dai J, Wang J, Cai J. National survey of patient specific IMRT quality assurance in China. Radiat Oncol. 2019 Apr 25;14(1):69. doi: 10.1186/s13014-019-1273-5. PMID: 31023348; PMCID: PMC6482589.
44: Wu T, Zhao Y, Wang H, Li Y, Shao L, Wang R, Lu J, Yang Z, Wang J, Zhao Y. mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors. Sci Rep. 2016 Feb 1;6:20250. doi: 10.1038/srep20250. PMID: 26833095; PMCID: PMC4735296.
45: Zhang W, Zhu Y, Zhou Y, Wang J, Jiang P, Xue L. miRNA-31 increases radiosensitivity through targeting STK40 in colorectal cancer cells. Asia Pac J Clin Oncol. 2021 Jun 25. doi: 10.1111/ajco.13602. Epub ahead of print. PMID: 34170070.
著作与译著
主编著作10部: 《放射性粒子组织间近距离治疗肿瘤》 《放射性粒子组织间近距离前列腺癌》 《放射性粒子组织间近距离治疗肿瘤—第二版》 《放射性粒子组织间近距离前列腺癌—第二版》 《放射性粒子治疗临床应用指南》 《放射治疗抉择》 《影像引导高剂量率后装精准近距离治疗学》 《肿瘤放射性粒子治疗规范》 《3D打印技术与精准粒子植入治疗学》 《3D打印技术与精准穿刺学》
中华医学会 主任委员