陈安滨医生简介

医学博士，现任上海交通大学医学院附属新华医院神经外科住院总医师及科研干事。
2016年至2022年期间在山东大学齐鲁医院硕博连读，获得博士学位，并被评为山东大学优秀博士毕业生。2022年博士毕业后，加入新华医院神经外科团队。2019年至2021年间，作为联合培养博士生在挪威卑尔根大学（University of Bergen）Neuro-SysMed研究中心进行深造，专攻人工诱导多能干细胞、神经干细胞、神经元、星形胶质细胞、类脑器官以及疾病模型药物筛选的前沿研究。在脑科学干细胞治疗及胶质瘤治疗领域进行了深入的基础研究，并以第一作者身份在《Advanced Science》《International Journal of Biological Sciences》《Cell Death and Disease》等国际期刊发表了10余篇研究型论文。
擅长诊断与治疗多种神经外科疾病，包括脑肿瘤、脑功能障碍以及脑血管相关疾病。

Dr. Anbin Chen holds a Ph.D. in Medicine and currently serves as the Chief Resident and Research Officer in the Department of Neurosurgery at Xinhua Hospital, affiliated with Shanghai Jiao Tong University School of Medicine. From 2016 to 2022, he pursued his combined Master's and Ph.D. studies at Qilu Hospital of Shandong University, where he earned his doctorate and was recognized as an Outstanding Doctoral Graduate of Shandong University. Upon graduating in 2022, he joined the neurosurgery team at Xinhua Hospital.
Between 2019 and 2021, Dr. Chen was a joint Ph.D. student at the Neuro-SysMed Research Center, University of Bergen, Norway, where he focused on cutting-edge research in induced pluripotent stem cells, neural stem cells, neurons, astrocytes, brain organoids, and disease model drug screening. His extensive basic research in the fields of brain science stem cell therapy and glioma treatment has led to the publication of over 10 research articles in international journals such as Advanced Science, International Journal of Biological Sciences, and Cell Death and Disease, where he is the first author.
Dr. Chen specializes in the diagnosis and treatment of various neurosurgical conditions, including brain tumors, brain function disorders, and cerebrovascular diseases.

上海市医师协会会员

1. Anbin Chen, Tsering Yangzom, Yu Hong, Bjørn Christian Lundberg, Gareth John Sullivan, Charalampos Tzoulis, Laurence A Bindoff, Kristina Xiao Liang, Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids, Advanced Science (2024), 2024 May;11(18).
2. Kristina Xiao Liang*, Anbin Chen*, Atefeh Kianian, Cecilie Katrin Kristiansen, Tsering Yangzom, Jessica Furriol, Lena Elise Høyland, Mathias Ziegler, Torbjørn Kråkenes, Charalampos Tzoulis, Evandro Fei Fang, Gareth John Sullivan, Laurence A. Bindoff, Activation of Neurotoxic Astrocytes Due to Mitochondrial Dysfunction Triggered by POLG Mutation, International Journal of Biological Sciences (2024), 2024; 20(8):2860-2880.
3. Jiwei Wang*, Anbin Chen*, Zhiwei Xue*, Junzhi Liu, Ying He, Guowei Liu, Zhimin Zhao, Wenjie Li, Qing Zhang, Anjing Chen, Jian Wang, Xingang Li, Xinyu Wang, Bin Huang, BCL2L13 promotes mitophagy through DNM1L-mediated mitochondrial fission in glioblastoma, Cell Death & Disease (2023), 2023 Sep 2;14(9):585.
4. Anbin Chen, Cecilie Katrin Kristiansen, Yu Hong, Atefeh Kianian, Evandro Fei Fang, Gareth John Sullivan, Jian Wang, Xingang Li, Laurence A. Bindoff, Kristina Xiao Liang, Nicotinamide Riboside and Metformin Ameliorate Mitophagy Defect in Induced Pluripotent Stem Cell-Derived Astrocytes With POLG Mutations, Frontiers in Cell and Developmental Biology (2021), 2021 Sep 24;9:737304.
5. Anbin Chen, Cecilie Katrin Kristiansen, Lena Elise Høyland, Mathias Ziegler, Jian Wang, Gareth John Sullivan, Xingang Li, Laurence A. Bindoff, Kristina Xiao Liang, POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition, Cell Cycle (2022), 2022 Mar 17;1-16.
6. Cecilie Katrin Kristiansen*, Anbin Chen*, Lena Elise Høyland, Mathias Ziegler, Gareth John Sullivan, Laurence A. Bindoff, Kristina Xiao Liang, Comparing the mitochondrial signatures in ESCs and iPSCs and their neural derivations, Cell Cycle (2022), 2022 Oct;21(20):2206-2221.
7. Kristina Xiao Liang*, Anbin Chen*, Cecilie Katrin Kristiansen, Laurence A. Bindoff, Flow Cytometric Analysis of Multiple Mitochondrial Parameters in Human Induced Pluripotent Stem Cells and Their Neural and Glial Derivatives, Journal of Visualized Experiments (2021), 2021 Nov 8;(177).
“*” indicates co-first authorship

8. Yu Hong, Zhuoyuan Zhang, Tsering Yangzom, Anbin Chen, Bjørn Christian Lundberg, Evandro Fei Fang, Richard Siller, Gareth John Sullivan, Jiri Zeman, Charalampos Tzoulis, Laurence A Bindoff, Kristina Xiao Liang, The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease, International Journal of Biological Sciences (2024), 2024 Jan 25;20(4):1194-1217.
9. Chao Zhang, Cheng-Fen Liu, An-Bin Chen, Zhong Yao, Wei-Guo Li, Shu-Jun Xu, Xiang-Yu Ma, Prognostic and Clinic Pathological Value of Cx43 Expression in Glioma: A Meta-Analysis, Frontiers in Oncology (2019), 2019 Nov 12;9:1209.
10. Xiaobing Yang, Di Lu, Yanfei Sun, Tiandi Wei Dulegeqi Man, Anbin Chen, Tao Luo, Feihu Zhao, Xuemeng Liu, Bo Cheng, Xu Wang, Peng Zhao, Donghai Wang, Xingang Li, Network pharmacology and experimental verification reveal the mechanism of safranal against glioblastoma, Frontiers in Oncology (2023), 2023 Sep. 1255164.
11. Sharika Marjan, Tsering Yangzom, Cecilie Katrin Kristiansen, Anbin Chen, Laurence A Bindoff, Kristina Xiao Liang, Application of Flow Cytometric Analysis for Measuring Multiple Mitochondrial Parameters in 3D Brain Organoids, Journal of Visualized Experiments (2023), 2023 Aug 4;(198).
12. Cecilie Katrin Kristiansen, Jessica Furriol, Anbin Chen, Gareth John Sullivan, Laurence A Bindoff, Kristina Xiao Liang, Deoxyribonucleoside treatment rescues EtBr-induced mtDNA depletion in iPSC-derived neural stem cells with POLG mutations, The FASEB Journal (2023), 2023 Sep;37(9):e23139.
13. Yu Hong, Cecilie Katrin Kristiansen, Anbin Chen, Gonzalo Sanchez Nido, Lena Elise Høyland, Mathias Ziegler, Gareth John Sullivan, Laurence A Bindoff, Kristina Xiao Liang, POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia, Experimental Neurology (2023), 2023 Jul;365:114429.
14. Zichao Feng, Wenjing Zhou, Jiwei Wang, Qichao Qi, Mingzhi Han, Yang Kong, Yaotian Hu, Yulin Zhang, Anbin Chen, Bin Huang, Anjing Chen, Di Zhang, Wenjie Li, Qing Zhang, Rolf Bjerkvig, Jian Wang, Frits Thorsen, Xingang Li, Reduced expression of proteolipid protein 2 increases ER stress-induced apoptosis and autophagy in glioblastoma, Journal of Cellular and Molecular Medicine (2020), 2020 Mar;24(5):2847-2856.
15. Kristina Xiao Liang, Guro Helén Vatne, Cecilie Katrin Kristiansen, Oleksandr Ievglevskyi, Elena Kondratskaya, Joel C Glover, Anbin Chen, Gareth John Sullivan, Laurence A Bindoff, N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation, Experimental Neurology (2021), 2021 Mar;337:113536.