汪国营医生简介

汪国营，男，主任医师，医学博士，博士生导师，从事肝胆胰脾外科临床工作20年，曾在美国印第安纳大学从事博士后研究一年。专业技术全面，临床业务扎实，对肝胆胰脾外科的常见病、多发病以及疑难杂病的诊治积累了丰富的临床经验，尤其对大范围肝切除手术、复杂和困难部位腹腔镜微创外科手术、原发性肝癌的规范化治疗、肝硬化门脉高压症的外科治疗、肝移植手术和围手术期管理、肝移植术后肝癌复发的防治以及常见并发症的防治等有深入研究。承担国家自然科学基金及省市级项目多项，入选首届树兰卓越工程肝移植青年人才海外研修计划、首批广东省杰出青年医学人才、广东省“千百十工程”培养对象，第一作者或通讯作者发表SCI及核心期刊论文60余篇，参编专著及教材5部，获国家发明专利1项。获国际性青年学者奖励6次、2015年广东省科技进步一等奖（排名第5）。

中国医师协会器官移植医师分会委员及移植管理学组委员、中国研究型医院学会普通外科学青年委员会副主任委员、欧美同学会医师协会肝胆分会委员、广东省肝脏病学会器官移植专业委员会副主任委员、广东省医学会微创外科学分会委员、广东省医学会肝癌分会委员、广东省医师协会器官移植医师分会秘书，中华消化外科菁英会移植外科学组副组长，中国抗癌协会胆管癌协助组专家委员会委员，国家自然科学基金、广东省自然科学基金、教育部学位中心学位论文评审专家。Frontiers in Oncology、Translational Cancer Research、Journal of Cancer Research Updates、中华肝脏外科手术学电子杂志、器官移植、岭南现代临床外科等杂志等杂志编委，Hepatology等杂志审稿专家。

曾获国际肝移植协会青年研究者奖3次、美国移植协会青年创新者奖、欧洲肝脏研究学会青年研究者奖、亚洲移植协会旅行奖等多项国际性奖励，是我国器官移植界获国际性奖励最多的青年学者之一。获2015年广东省科学技术进步奖一等奖（R5），指导学生获2015年第六届全国高等医学院校大学生临床技能竞赛一等奖。

第一/通讯作者英文期刊论文30多篇，中文核心期刊论文30多篇：
1. Rongqiang Liu(＃), Tianxing Dai(＃), Shiyang Zheng(＃), Mingbin Deng, Guozhen Lin, Yuanda Bao, Zhihua Guo(*), Guoying Wang(*). Prognostic value of combined pretreatment fibrinogen and neutrophil-lymphocyte ratio in digestive system cancers: a meta-analysis of 17 retrospective studies. Translational Cancer Research. 2021;10(1):241-250.
2. Weihao Kong(＃), Mingwei Yang(＃), Jianfeng Zhang(＃), Ya Cheng, Tianxing Dai, Jian Zhang, Guoying Wang(*), Jianlin Zhang(*). Prognostic value of inflammation-based indices in patients with resected hepatocellular carcinoma. BMC Cancer. 2021;21:469.
3. Jian-Wen Zhang, Zhen-Yu Yu, Hai-Bo Li, Shu-Hong Yi, Wei Liu, Yang Yang(*), Guo-Ying Wang(*). Severe bile duct complication after Yttrium-90 radioembolization therapy in a patient with recurrent hepatocellular carcinoma after liver transplantation: A case report. Liver Research. 2021;5:33-35
4. Zhiyu Qiu(＃), Lujun Shen(＃), Yiquan Jiang(＃), Jiliang Qiu, Zining Xu, Mengting Shi, Zhentao Yu, Yanping Ma, Wei He, Yun Zheng, Binkui Li, Guoying Wang(*), Yunfei Yuan(*). Transarterial chemoembolization (TACE) combined with apatinib versus TACE combined with sorafenib in advanced hepatocellular carcinoma patients: A multicenter retrospective study. Annals of Translational Medicine. 2021;9(4):283.
5. Tianxing Dai(＃), Mingbin Deng(＃), Linsen Ye(＃), Guozhen Lin, Rongqiang Liu，Yinan Deng, Rong Li, Wei Liu, Hua Li, Yang Yang, Guihua Chen, Guoying Wang(*). Nomogram based on clinicopathological factors and inflammatory indicators for prediction of early and late recurrence of HCC after surgical resection for patients with chronic hepatitis B. Annals of Translational Medicine. 2021;9(1):12 | http://dx.doi.org/10.21037/atm-20-1353.
6. Changchang Jia(＃), Guoying Wang(＃), Tiantian Wang(＃), Binsheng Fu, Yincai Zhang, Lei Huang, Yinan Deng, Guanzhong Chen, Xiaocai Wu, Jianning Chen, Yuhang Pan, Yan Tai, Jinliang Liang, Xuejiao Li, Kunhua Hu Bo Xie, Sujun Li, Yang Yang, Guihua Chen(*), Qi Zhang(*), Wei Liu(*). Cancer-associated Fibroblasts induce epithelial-mesenchymal transition via the Transglutaminase 2-dependent IL-6/IL6R/STAT3 axis in Hepatocellular Carcinoma. International Journal of Biological Sciences. 2020;16(14):2542-2558.
7. Linsen Ye, Yingcai Zhang, Hui Tang, Jia Yao, Guoying Wang(*), Yang Yang, Guihua Chen. Prediction of chronic kidney disease progression used by calcineurin inhibitor concentration and estimated glomerular filtration rate early after liver transplantation. Nigerian Journal of Clinical Practice. 2020;23:1387-94.
8. Shuguang Zhu, Haibo Li, Zenan Yuan, Wei Liu, Qing Yang , Ying Cheng, Wenjing Wang, Guoying Wang(*), Hua Li. Achievement of complete response to nivolumab in a patient with advanced sarcomatoid hepatocellular carcinoma: A case report. World Journal of Gastrointestinal Oncology. 2020; 12(10): 1209-1215.
9. Tianxing Dai(＃), Mingbin Deng(＃), Linsen Ye, Rongqiang Liu, Guozhen Lin, Xiaolong Chen, Hua Li, Wei Liu, Yang Yang, Guihua Chen, Guoying Wang(*). Prognostic value of combined preoperative gamma-glutamyl transpeptidase to platelet ratio and fibrinogen in patients with HBV-related hepatocellular carcinoma after hepatectomy. American Journal of Translational Research. 2020;12(6):2984-2997.
10. Tianxing Dai, Guozhen Lin, Mingbin Deng, Shuguang Zhu, Haibo Li, Jia Yao, Hua Li, Wei Liu, Yang Yang, Guihua Chen, Guoying Wang(*). The prognostic significance of neutrophil-to-lymphocyte ratio at different time points in patients with hepatocellular carcinoma receiving liver resection. Translational Cancer Research. 2020; 9(2):441-457.
11. Yi-Quan Jiang(＃), Su-E Cao(＃), Shilei Cao(＃), Jian-Ning Chen(＃), Guo-Ying Wang(＃), Wen-Qi Shi, Yi-Nan Deng, Na Cheng , Kai Ma, Kai-Ning Zeng, Xi-Jing Yan, Hao-Zhen Yang, Wen-Jing Huan, Wei-Min Tang, Yefeng Zheng, Chun-Kui Shao, Jin Wang, Yang Yang(*), Gui-Hua Chen(*). Preoperative identification of microvascular invasion in hepatocellular carcinoma by XGBoost and deep learning. Journal of Cancer Research and Clinical Oncology. 2020; doi: 10.1007/s00432-020-03366-9. Online ahead of print.
12. Guoying Wang(＃), Wei Liu(＃), Yong Zou(＃), Genshu Wang, Yinan Deng, Jingyan Luo, Yingcai Zhang, Hua Li, Qi Zhang(*), Yang Yang(*), Guihua Chen(*). Three isoforms of exosomal circPTGR1 promote hepatocellular carcinoma metastasis via the miR449a-MET pathway. EBioMedicine. 2019; 40:432-445.
13. Kai-Ning Zeng, Ying-Cai Zhang, Gen-Shu Wang, Jian Zhang, Yi-Nan Deng,Shi-Hui Li,QiZhang, Hua Li, Guo-Ying Wang(*),Yang Yang(*), Gui-Hua Chen. A scoring model based on plasma fibrinogen concentration for predicting recurrence of hepatocellular carcinoma after liver transplantation. Liver Research. 2019; 3(3-4): 234-239.
14. Tianxing Dai(＃), Lingrong Peng(＃), Guozhen Lin, Yang Li, Jia Yao, Yinan Deng, Hua Li, Genshu Wang, Wei Liu, Yang Yang, Guihua Chen, Guoying Wang(*). Preoperative elevated plasma fibrinogen level predicts tumor recurrence and poor prognosis in patients with hepatocellular carcinoma. Journal of Gastrointestinal Oncology. 2019; 10(6): 1049-1063.
15. Linsen Ye(＃), Rongpu Liang(＃), Jiebin Zhang, Chaojin Chen, Xiaolong Chen, Yi Zhang, Guoying Wang(*), Yang Yang(*), Guihua Chen. Postoperative albumin-bilirubin grade and albumin-bilirubin change predict the outcomes of hepatocellular carcinoma after hepatectomy. Annals of Translational Medicine. 2019; 7(16):367.
16. Yiquan Jiang(＃); Zixian Wang(＃); Yinan Deng(＃); Yang Yang; Guoying Wang(*); Guihua Chen(*). Efficacy of Hepatic Resection versus Radiofrequency Ablation for Patients with Very-Early-Stage or Early-Stage Hepatocellular Carcinoma: A Population-Based Study with Stratification by Age and Tumour Size. Frontiers in Oncology, 2019, 9: 1-10.
17. Yiquan Jiang(＃); Hui Tang(＃); Zixian Wang; Yuanjing Sun; Wei Meng; Guoying Wang(*); Hua Li; Shuhong Yi; Genshu Wang; Yang Yang; Guihua Chen(*). Two Nomograms to Select Hepatocellular Carcinoma Patients with Macroscopic Vascular Invasion for Hepatic Resection. Journal of Cancer, 2018, 9(18): 3287-3294 .
18. Zhenyu Yu(＃); Wei Liu; Yinan Deng; Jia Yao; Hui Tang; Hua Li; Yang Yang; Guoying Wang(*); Guihua Chen. Significant Efficacy of Apatinib in a Patient With Hepatocellular Carcinoma Lung Metastases After Liver Transplantation. Transplantation Proceedings, 2018, 50(10): 4042-4045
19. Yi-Sheng Wei(＃); Ya-Guang Zhou; Guo-Ying Wang(*); Zhi-Hua Liang; Min-Rui Luo; Tian-Ai Yang; Jun Huang (*). The impact of chemotherapy-associated hemoglobin on prognosis of colorectal cancer patients receiving adjuvant chemotherapy. Cancer Biomarkers, 2017, 20(4): 627-635.
20. Zenan Yuan(＃); Jian Zhang(＃); Yong Huang(＃); Yingcai Zhang; Wei Liu; Genshu Wang; Qi Zhang; Guoying Wang(*); Yang Yang; Hua Li(*); Guihua Chen(*). NRF2 overexpression in mesenchymal stem cells induces stem-cell marker expression and enhances osteoblastic differentiation. Biochemical and Biophysical Research Communications, 2017, 491(1): 228-235.
21. Zhenyu Yu(＃); Jian Zhang; Yingcai Zhang; Wei Liu; Jia Yao; Hui Tang; Haibo Li; Genshu Wang; Guoying Wang(*); Yang Yang; Guihua Chen. Study on efficacy and prognostic indicators of sorafenib in advanced hepatocellular carcinoma. Digestive System, 2017, 1(2): 1-4.
22. Guo-Ying Wang(＃)(*) ; Nan Jiang; Hui-Min Yi; Gen-Shu Wang; Jian-Wen Zhang; Hua Li; Jian Zhang; Qi Zhang; Yang Yang; Gui-Hua Chen. Pretransplant Elevated Plasma Fibrinogen Level is a Novel Prognostic Predictor for Hepatocellular Carcinoma Recurrence and Patient Survival Following Liver Transplantation. Annals of Transplantation, 2016, 21: 125-130.
23. Yong Zou(＃); Junjie Bao(＃); Xingfei Pan; Ying Lu; Sihong Liao; Xicheng Wang; Guoying Wang(*); Dongjun Lin(*). NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure. PLoS One, 2015, 10(8): e0134568.
24. Nan Jiang(＃); Wen-Jie Chen(＃); Jian-Wen Zhang(＃); Chi Xu; Xian-Cheng Zeng; Tong Zhang; Yang Li; Guo-Ying Wang(*). Downregulation of miR-432 activates Wnt/β-catenin signaling and promotes human hepatocellular carcinoma proliferation. Oncotarget, 2015, 6(10): 7866-7879.
25. Yinan Deng(＃); Shuhong Yi(＃); Guoying Wang(＃); Jintao Cheng; Yingcai Zhang; Wenjie Chen; Yan Tai; Shaohong Chen; Guihua Chen; Wei Liu; Qi Zhang(*); Yang Yang(*). Umbilical Cord-Derived Mesenchymal Stem Cells Instruct Dendritic Cells to Acquire Tolerogenic Phenotypes through the IL-6-Mediated Upregulation of SOCS1. Stem Cells and Development, 2014; 23(17): 2080-2091.
26. Guo-Ying Wang(＃); Hua Li; Wei Liu; Jian Zhang; Huan-Bing Zhu; Gen-Shu Wang; Qi Zhang; Yang Yang; Gui-Hua Chen(*), Elevated Blood Eosinophil Count Is a Valuable Biomarker for Predicting Late Acute Cellular Rejection After Liver Transplantation , Transplantation Proceedings, 2013.4, 45(3): 1198-1200.
27. Guo-Ying Wang(＃); Yang Yang; Hua Li; Jian Zhang; Min-Ru Li; Qi Zhang; Gui-Hua Chen(*), Rapamycin combined with donor immature dendritic cells promotes liver allograft survival in association with CD4+CD25+Foxp3+regulatory T cell expansion, Hepatology Research, 2012.2, 42(2): 192-202.
28. Guo-Ying Wang(＃); Qi Zhang; Yang Yang; Wen-Jie Chen; Wei Liu; Nan Jiang; Gui-Hua Chen(*), Rapamycin combined with allogenic immature dendritic cells selectively expands CD4(+)CD25(+)Foxp3(+) regulatory T cells in rats, Hepatobiliary and Pancreatic Diseases International, 2012.4, 11(2): 203-208.
29. Guo-Ying Wang(＃); Yang Yang; Hua Li; Jian Zhang; Nan Jiang; Min-Ru Li; Huan-Bing Zhu; Qi Zhang(*); Gui-Hua Chen(*). A Scoring Model Based on Neutrophil to Lymphocyte Ratio Predicts Recurrence of HBV-Associated Hepatocellular Carcinoma after Liver Transplantation, PLoS One, 2011, 6(9): 1-9.
30. Guo-Ying Wang(＃); Gui-Hua Chen(*); Hua Li; Yong Huang; Jian Zhang; Nan Jiang; Wei-Jin Chen. Rapamycin Inhibits Activator Protein 1 But Not Nuclear Factor κB Activity of Mature Bone Marrow Derived Dendritic Cells. Transplantation proceedings, 2010, 42(6):1881-1883.
31. Guo-Ying Wang(＃); Gui-Hua Chen(＃)(*); Hua Li; Yong Huang; Gen-Shu Wang; Nan Jiang; Bin-Sheng Fu. Rapamycin-treated mature dendritic cells have a unique cytokine secretion profile and impaired allostimulatory capacity. Transplant International, 2009, 22(10):1005-1016.
32. Guo-Ying Wang. Differential microRNA expression in peripheral blood might be used to predict immune status after solid organ transplantation. Journal of Gastric Disorders and Therapy, 2016;2(2): doi http://dx.doi. org/10.16966/2381-8689.116.