非小细胞肺癌患者经皮穿刺活检或支气管镜活检不会增加复发

Recurrence risk after preoperative biopsy in patients with resected early-stage non-small-cell lung cancer: a retrospective study.

切除的早期非小细胞肺癌患者术前活检后的复发风险：一项回顾性研究。

Abstract摘要

BACKGROUND:背景：

Tumor cell dissemination after needle biopsy has been reported in a variety of malignancies, including non-small-cell lung cancer (NSCLC).

在各种恶性肿瘤，包括非小细胞肺癌（NSCLC）中，已报道针吸活检后肿瘤细胞播散。

However, there is little clinical evidence in regard to whether preoperative biopsy increases the risk of recurrence in completely resected NSCLC.

然而，关于术前活检是否会增加完全切除的NSCLC复发风险的临床证据很少。

PATIENTS AND METHODS:

患者和方法：

A total of 322 patients diagnosed as pathological stage I NSCLC using intraoperative biopsy (IOB) (control group), preoperative percutaneous needle biopsy (PNB) or bronchoscopic biopsy were included in this study.

本研究共纳入322例经术中活检（IOB）（对照组）、术前经皮穿刺活检（PNB）或支气管镜活检确诊的病理Ⅰ期NSCLC。

Baseline characteristics were collected and compared.

收集并比较基线特征。

The disease-free survival (DFS) of patients was analyzed using Kaplan-Meier method.

使用Kaplan-Meier法分析患者的无病生存率（DFS）。

Subgroup analysis and Cox regression were performed to evaluate the effect of preoperative biopsy on recurrence risk with adjustment for potential confounders.

亚组分析和Cox回归评估术前活检对复发风险的影响，并校正潜在的混杂因素。

RESULTS:结果：

Among these patients, 202 (63%) underwent IOB, 66 (20%) underwent PNB, and 54 (17%) underwent bronchoscopic biopsy.

在这些患者中，202例（63％）接受了IOB，66例（20％）接受了PNB，54例（17％）接受了支气管镜活检。

DFS of patients who had preoperative PNB or bronchoscopic biopsy was similar to those who had IOB (P=0.514 and 0.869).

术前PNB或支气管镜活检患者的DFS与IOB患者相似（P=0.514和0.869）。

Neither preoperative PNB nor transbronchial biopsy significantly affected recurrence incidence across all the relevant subgroups.

术前PNB和经支气管活检均未显著影响所有相关亚组的复发率。

Furthermore, multivariate analysis showed that preoperative biopsy was not associated with increased recurrence risk in NSCLC patients with adjustment for confounders, while squamous cell carcinoma and adjuvant chemotherapy were associated with prolonged DFS.

此外，校正混杂因素的多变量分析显示，术前活检与NSCLC患者的复发风险增加无关，而鳞状细胞癌和辅助化疗与DFS延长相关。

CONCLUSION:结论：

Neither preoperative PNB nor bronchoscopic biopsy increased the recurrence risk in patients with resected stage I NSCLC, indicating that these procedures could be safely used for diagnosis of early-stage NSCLC.

术前PNB和支气管镜活检均未增加切除的I期NSCLC患者的复发风险，表明这些措施可安全地用于早期NSCLC的诊断。

doi: 10.2147/CMAR.S166930.