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脑转移癌的治疗现状

魏社鹏 副主任医师 上海市东医院 神经外科
2009-07-07 940人已读
魏社鹏 副主任医师
上海市东医院
脑转移癌的治疗现状

Current Management of Metastatic Brain Disease

 

    脑转移癌是成人最常见的脑瘤。人类对系统性肿瘤的检测和治疗技术的巨大进步造就了脑转移癌发病率连年上升。磁共振技术的广泛使用导致了脑部转移瘤的早期发现。上海市杨浦区市东医院神经外科魏社鹏

    现有的证据表明,当给以激进的治疗之后,脑转移癌的生存期和生活质量都会有明显的延长和改善。

    脑转移癌治疗方法的选用要参考原发肿瘤的分期,组织病理,病人年龄和行动状态,脑部病变的数目,大小和位置。

    目前的证据支持,全脑放疗配合伽码刀技术或者手术能显著改善病人的生存期,认知功能以及生活质量。化疗的使用以及放疗增敏剂的使用是否能提高生存期,尚没有证据支持。

 

Neurotherapeutics, 07/06/09

Tulika Ranjan, Lauren E. Abrey

Brain metastases are the most common intracranial tumor in adults. The incidence of metastases is thought to be rising due to better detection and treatment of systemic malignancy. More widespread use and improved quality of MRI may lead to early detection of brain metastases. Available evidence suggests that survival is longer and quality of life improved if brain metastases are treated aggressively. This article reviews current therapeutic management used for brain metastases. To select the appropriate therapy, the physician must consider the extent of the systemic disease, primary histology, and patient age and performance status, as well as the number, size, and location of the brain metastases. Available treatment options include whole-brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), surgery, and chemotherapy. Multidisciplinary approaches such as the combination of WBRT with SRS or surgery have shown superior results in terms of survival time, neurocognitive function, and quality of life. The utility and optimal use of chemotherapy and radiosensitizing agents is less clear. It is hoped that further advances and multidisciplinary approaches currently under study will result in improved patient outcomes.

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魏社鹏 副主任医师

上海市东医院 神经外科

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