首页 我的

原创 联合TACE和RFA治疗大肝癌

王茂强 主任医师 北京301医院 介入放射科
2013-10-21 235人已读
王茂强 主任医师
北京301医院

World J Gastroenterol. 2013 Jul 14;19(26):4192-9. doi: 10.3748/wjg.v19.i26.4192.

Transcatheter arterial chemoembolization followed by immediate radiofrequency
ablation for large solitary hepatocellular carcinomas.

Wang ZJ, Wang MQ, Duan F, Song P, Liu FY, Chang ZF, Wang Y, Yan JY, Li K.中国人民解放军总医院(301医院)介入放射科王茂强

Department of Interventional Radiology, PLA General Hospital, Beijing 100853,
China.

AIM: To assess the technical safety and efficacy of transcatheter arterial
chemoembolization (TACE) combined with immediate radiofrequency ablation (RFA)
for large hepatocellular carcinomas (HCC) (maximum diameter ≥ 5 cm).
METHODS: Individual lesions in 18 patients with HCCs (mean maximum diameter: 7.5
cm; range: 5.1-15.5 cm) were treated by TACE combined with percutaneous RFA
between January 2010 and June 2012. All of the patients had previously undergone
one to four cycles of TACE treatment. Regular imaging and laboratory tests were
performed to evaluate the rate of technical success, technique-related
complications, local-regional tumor responses, recurrence-free survival time and
survival rate after treatment.
RESULTS: Technical success was achieved for all 18 visible HCCs. Complete
response (CR) was observed in 17 cases, and partial response was observed in 1
case 1 mo after intervention. The CR rate was 94.4%. Local tumors were mainly
characterized by coagulative necrosis. During follow-up (2-29 mo), the mean
recurrence-free survival time was 16.8 ± 4.0 mo in 17 cases of CR. The estimated
overall survival rate at 6, 12, and 18 mo was 100%. No major complications were
observed. Levels of alanine aminotransferase (ALT) and aspartate aminotransferase
(AST) in the blood of 17 patients transiently increased on the third day after
treatment (ALT 200.4 ± 63.4 U/L vs 24.7 ± 9.3 U/L, P < 0.05; AST 228.1 ± 25.4 U/L
vs 32.7 ± 6.8 U/L, P < 0.05). Severe pain occurred in three patients, which was
controlled with morphine and fentanyl.
CONCLUSION: TACE combined with immediate RFA is a safe and effective treatment
for large solitary HCCs. Severe pain is a major side effect, but can be
controlled by morphine.

PMCID: PMC3710422

有帮助
期待更新

王茂强 主任医师

北京301医院 介入放射科

问医生 去挂号

更多文章

联合TACE和RFA治疗... 的相关咨询
联合TACE和RFA治疗... 的相关疾病
由于相关规范,IOS用户暂不可在小程序订阅