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原创 即时性TACE和RFA治疗HCC

王茂强 主任医师 北京301医院 介入放射科
2013-10-21 411人已读
王茂强 主任医师
北京301医院

Asian Pac J Cancer Prev. 2013;14(3):1649-54.

Clinical application of transcatheter arterial chemoembolization combined with
synchronous C-arm cone-beam CT guided radiofrequency ablation in treatment of
large hepatocellular carcinoma.

Wang ZJ, Wang MQ, Duan F, Song P, Liu FY, Wang Y, Yan JY, Li K, Yuan K.中国人民解放军总医院(301医院)介入放射科王茂强

Department of Interventional Radiology, PLA General Hospital, Beijing, China.
maoqiangwang@yeah.net

OBJECTIVE: This work aimed to evaluate the safety and clinical efficacy of
transcatheter arterial chemoembolization (TACE) combined with c-arm cone-beam CT
guided synchronous radiofrequency ablation (RFA) in treatment of large
hepatocellular carcinoma (HCC).
METHODS: 21 patients with large HCC were studied from January 2010 to March 2012.
TACE combined with synchronous C-arm cone-beam CT guided RFA were performed on a
total of 25 lesions. Conventional imaging examination (CEUS, enhanced CT or MRI)
and AFP detection were regularly conducted to evaluate the technical success rate
of combined treatment, complications, treatment response, time without disease
recurrence and survival rate.
RESULTS: The technical success rate of combined treatment was 100%, without any
significant complication. After 1 month, there were 19 cases with complete
response and 2 cases with partial response, with an complete response rate of
90.4% (19/21) and a clinical effective rate of 100% (21/21). The complete
response rates of single nodular lesions (100%, 17/17) was significantly higher
than that of multiple nodular lesions (50%, 2/4) (P < 0. 05). During 2 to 28
months of follow- up, in 19 cases with complete response, the average time
without disease recurrence was 10.8 ± 6 months. The total survival rates of 6, 12
and 18 months in 21 patients were 100%, respectively.
CONCLUSION: TACE combined with synchronous C-arm CT guided RFA is safe and
effective for treatment of large HCC. The treatment efficacy for single nodular
lesion is better than that for multiple nodular lesions.

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王茂强 主任医师

北京301医院 介入放射科

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