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孟国明 副主任医师
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角膜塑形镜对比阿托品控制近视研究

2014-08-10 毛欣杰选编 IAOA小秘书 好大夫工作室眼科孟国明

Overnight orthokeratology is comparable with atropine in controlling myopia.

BMC Ophthalmol. 2014 Mar

Lin HJ, Wan L, Tsai FJ, Tsai YY, Chen LA, Tsai AL, Huang YC1.

1Department of Medical Research, China Medical University Hospital, No, 2 Yuh Der Road, Taichung 404, Taiwan. irisluu2396@yahoo.com.tw.


Background背景

Many efforts have been invested in slowingprogression of myopia. Among the methods, atropine administration andorthokeratology (OK) are most widely used. This study analyzed the efficacy ofatropine and OK lens in controlling myopia progression and elongation of axiallength.



有许多方法被认为可能减缓近视的发展。在这些方法中,阿托品管理和角膜塑形术(OK)被广泛使用。本研究分析阿托品和角膜塑形术在控制近视发展和眼轴增长的作用。

Methods方法

This retrospective study included 105 patients (210eyes) who wore OK lenses and 105 patients (210 eyes) who applied 0.125%atropine every night during the 3 following period. Student t-test,linear regression analysis, repeated measure ANOVA, and Pearson’s correlationcoefficient were used for statistical analysis.
这项回顾性研究共纳入配戴OK镜片105例(210眼),和每天晚上使用0.125%的阿托品105例(210眼),连续使用3个随访时间。t检验,线性回归分析,重复测量的方差分析和Pearson相关系数进行统计分析。

Results结果

The change in axial length per yearwas 0.28±0.08 mm, 0.30±0.09 mm, and 0.27±0.10 mm in the OK lens group, and 0.38±0.09 mm, 0.37±0.12 mm, and 0.36±0.08 mm in the atropine group for years 1, 2, and 3, respectively.Linear regression analysis revealed an increase in myopia of 0.28 D and 0.34 Dper year, and an increase in axial length of 0.28 mm and 0.37 mm peryear in the OK lens and atropine groups, respectively. Repeated measure ANOVAshowed significant differences in myopia (p=0.001) and axial length (p<0.001) between the atropine and OK lens groups; in astigmatism, there wasno significant difference in these parameters (p=0.320). Comparison of increases in axial length in relation to baselinemyopia showed significant correlations both in the OK lens group (Pearson’scorrelation coefficient, r=0.259; p<0.001) and atropine group (r=0.169; p=0.014). High myopia patients benefited more from both OK lenses andatropine than did low myopia patients. The correlation of baseline myopia andmyopia progression was stronger in the OK lens group then in the atropinegroup.
3
年的随访中,角膜塑形镜的每年的眼轴增长的变化分别为0.28±0.08mm0.30±0.09mm,和0.27±0.10mm,而阿托品组是0.38±0.09mm0.37±0.12mm,和0.36±0.08mm。线性回归分析表明角膜塑形镜每年增加了0.28 D近视、眼轴增长了0.28毫米,阿托品组每年0.34D近视和每年0.37mm的眼轴增长。重复测量方差分析表明,阿托品和OK镜组之间近视增加差异有显著(p=0.001),眼轴长度增加也有差异性(P<0.001< span="">;散光,有在这些参数(p=0.320)无显著差异。近视眼眼轴长度的增加在两组中,都和之前的近视度数高低有显著相关,OK镜组(Pearson相关系数r=0.259P<0.001< span="">)和阿托品组相关(r =0.169P=0.014)。OK镜片和阿托品组中相对高度近视患者比低度近视患者对近视控制效果更好OK镜组比阿托品组,近视进展控制相对基准近视度数的相关性更强。



Conclusions结论

OK lens is a useful method for controlling myopiaprogression even in high myopia patients.
OK
镜是用于控制近视,即使在高度近视患者的近视进展,也是一种有效的方法。
Keywords: Atropine, Axial length, Corneaendothelium, Myopia, Orthokeratology

关键词:阿托品,眼轴,角膜内皮,近视,角膜塑形术

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