【郭玉兴】北大口腔医院 - 口腔颌面外科 - 医生门诊时间 - 预约挂号 - 在线问诊

擅长

擅长口腔颌面部肿瘤（涎腺肿瘤、口腔癌、颌骨囊肿）、颌面组织缺损修复（舌、颊、下颌骨缺损修复重建）、药物相关性颌骨骨髓炎（MRONJ）的诊断和治疗（手术治疗效果不确定性较大，建议非必要不手术，谨慎决策手术）。

简介

郭玉兴，男，河北唐山人，九三学社社员。现为北京大学口腔医院口腔颌面外科副主任医师、副研究员、副教授、博士研究生导师。2022年曾兼职北京大学国际医院口腔颌面外科副主任。2023年2月开始担任北京大学口腔医院-保定市第二医院口腔专科医联体项目负责人，保定市第二医院口腔院区学术院长。2024年7月起兼任华北理工大学口腔医学院硕士研究生导师。2016年至2018年于美国南加州大学牙学院进行访问学者学习，专注于BMP信号通路为介导的颅缝微环境、牙源性干细胞调控和骨稳态免疫调控研究，并进行3D生物打印材料修复临界骨缺损的相关研究工作，发表5篇高水平SCI文章和1项美国专利，相关研究工作发表Bone research、Development、Journal of Dental Research、Bio-Design and Manufacturing和ACS biomaterials science & engineering杂志发表。

多年从事口腔颌面肿瘤（口腔癌，舌癌，牙龈癌等；腮腺肿瘤）、颌面组织缺损修复（舌缺损，下颌骨缺损）和药物相关性颌骨骨髓炎（唑来膦酸、地舒单抗、安罗替尼、仑伐替尼、贝伐珠单抗）的临床与基础研究。

Yuxing Guo, MD is a graduate of Peking University School of Stomotology, where he also attended his postgraduate studies, where graduated Hebei Medical University School of Stomotology with a Bachelor of Dental Surgery. Dr.Guo trained at the Peking University Hospital of Stomotology in Beijing at the Department of Oral and Maxillofacial Surgery. During his residency, he was able to carry out many operations of oral and maxillofacial oncology and rehabilitation, such as oral oncology resection, neck dissection, free flaps harvest, while simultaneously completing a clinical research of navigation-guided surgery. He eventually was licensed and began his career as a maxillofacial surgeon there. Afterwards, he completed a fellowship and postdoc training at Herman Ostrow School of Dentistry of USC, Center for Craniofacial Molecular Biology, with a publication related of the interplay between mesenchymal stem cells and osteoclast.

Dr.Guo has been practicing in the Department of Oral and Maxillofacial Surgery at Peking University Hospital of Stomotology in Beijing since 2014, one of the top five oral cancer hospitals in China. His practice focuses on oral and maxillofacial oncology and rehabilitation, clinical treatment of medication-related osteonecrosis of the jaw (MRONJ), and basic research of cancer stem cells, drug resistance and bony invasion of oral squamous cell carcinoma. His research has been supported by the National Natural Science Foundation of China, Beijing Municipal Science and Technology Commission, Peking University Health Center, and Peking University Hospital of Stomatology. One of his hobbies is mentoring younger students and devotes time to running teaching and educational seminars for young students interested in the sciences and medicine. He currently has 10 English publications in maxillofacial-surgery field journals and over 10 Chinese publications. He is listed as an expert to treatment of medication-related osteonecrosis of the jaw (MRONJ) in China, currently according to therapy management dependent on MRONJ staging tailored to a patient’s individual drug-using history.

Currently, Dr.Guo holds certification from the Oral and Maxillofacial-Head and Neck Cancer Committee of the Chinese Stomatological Association as a young border member. He was also awarded by Qiu Wei Liu Oral & Maxillofacial Surgery Development Foundation, and Science Technology Improvement Award of Science Research Achievement Award in Higher Education Institution of China for his contributions to navigation-guided surgery developments in the field of skull base tumors.

社会任职

中国抗癌协会头颈肿瘤专委会委员
中华口腔医学会口腔颌面-头颈肿瘤专委会委员
中国医疗保健国际交流促进会颅底外科分会常委/秘书长
中国抗癌协会国际医疗交流专委会委员
北京医学会口腔医学分会常委及学术秘书
北京癌症防治学会头颈部黑色素瘤专委会委员
北京口腔医学会口腔颌面外科专委会委员
中国整形美容协会形塑与综合技术转化分会理事
北京医学奖励基金会肺癌医学青年专家委员会肺癌转移性骨病MDT协作组组员
北京市科协人才举荐评审专家
河北省口腔医学会口腔颌面外科专委会副主任委员
北京市海淀区医学会口腔医学专业委员会副主任委员
《中华口腔医学研究杂志（电子版）》青年编委
《世界耳鼻咽喉头颈外科杂志（英文）》通讯编委
《北京口腔医学》杂志编委
《Cell Proliferation》、《Scientific Report》、《PloS One》、《Cell Cycle》审稿人
《中国生物化学与分子生物学报》审稿人

获奖荣誉

入选北京大学口腔医院第一梯队（2019年）/第二（2014年）梯队科研人才培养计划
2018年获邱蔚六口腔颌面外科发展基金“希望奖”
北京口腔医学年会口腔外科病例报告比赛一等奖
2019年获高等学校科学研究科学技术进步二等奖（第三完成人）
2022年中国健康长寿大赛三等奖

科研成果

主持国自然基金1项，国家重点研发计划子课题1项，北京首都特色临床研究项目1项，北京市自然科学基金面上项目1项，北京大学校/院项目，等共计11项。
1）国家口腔医学中心适宜技术推广项目，药物相关领骨骨坏死外科治疗技术的推广应用，在研，主持
2）北京大学临床医学+X青年专项，面向手术导航用拉曼光谱与 AI 技术识别口腔颌面坏死骨-正常骨边界的前期探索研究，2023/01-2023/12，主持。
3）第三届中国健康长寿创新大赛立项项目，新型自组装防御肽水凝胶改善化疗后口腔粘膜愈合障碍的技术开发，2022/09-2022/08，主持。
4）北京大学口腔医院国家临床重点专科建设项目，基于高光谱成像技术的术中坏死骨识别人工智能辅助诊断系统的研发与验证，2022/01-2024/12，主持。
5）北京市自然基金委面上项目，BMP介导的肿瘤相关巨噬细胞极化状态促进口腔鳞状细胞癌进展的作用机制研究，2021/01-2023/12，主持。
6）北京大学口腔医院临床新技术新疗法项目, 翻瓣联合骨管拔牙技术在药物相关颌骨骨髓炎潜在风险患者中的临床应用研究，2020/11-2022/03，主持。
7）国家重点研发计划，骨科智能设计与仿生制造医学关键技术研究及临床验证，2020/06-2023/05，子课题负责人。
8）国家自然科学基金青年项目，BMP介导的骨免疫调控改善骨质疏松条件下口腔种植体骨结合力的可行性及机制研究，2020/01-2022/12，主持。
9）北大医学青年科技创新培育基金项目，2019/01-2019/12，主持。
10）首都临床特色应用研究项目，多模态影像导航技术引导颅底-颞下区肿瘤的精准治疗，2016/06-2019/6，主持。
11）北京大学口腔医院青年科研基金，I型胶原羧基末端肽在动物建模中预测双膦酸盐颌骨骨髓炎发生的探索研究，2014/06-2016/06（获滚动资助），主持。

授权发明专利1项。
专利名称：种骨组织结构状态检测方法。专利授权号：2024010401751630

迄今以第一作者或通讯作者发表论文40余篇（其中SCI22篇，总影响因子＞60）。
近5年发表文章：
[1]Li Q, Zhang X, Zhang J, Huang H, Li L, Guo C, Li W, Guo Y. Deep learning-based hyperspectral technique identifies metastatic lymph nodes in oral squamous cell carcinoma-A pilot study. Oral Dis. 2024 Jul 15. doi: 10.1111/odi.15067
[2]Huang, H., Qiao, Q., Zhao, N., Zhou, Y., Zou, Y., Li, Q., Li, S., Zhou, B., Zhang, Y., Guo, C., & Guo, Y. (2024). Efficacy of submental island flap closing advanced mandibular MRONJ lesion in malignancy patients. Head & neck, 46(9), 2315–2326. https://doi.org/10.1002/hed.27837
[3]Zhang X, Li Q, Li W*, Guo Y*, Zhang J, Guo C, Chang K, Lovell NH. FD-Net: Feature Distillation Network for Oral Squamous Cell Carcinoma Lymph Node Segmentation in Hyperspectral Imagery. IEEE J Biomed Health Inform. 2024;28(3):1552-1563. doi: 10.1109/JBHI.2024.3350245.(Q2，IF=7.7，共同通讯）
[4]周颖,赵宁,黄竑远,李庆祥,郭传瑸,郭玉兴. 双层软组织缝合封闭技术在下颌骨中早期药物相关性颌骨骨坏死患者手术治疗中的应用[J]. 北京大学学报（医学版）, 2024, 56(1): 51-56.（通讯作者）
[5]Li Q, Li Y, Qiao Q, Zhao N, Yang Y, Wang L, Wang Y, Guo C*, Guo Y*. Oral administration of Bifidobacterium breve improves anti-angiogenic drugs-derived oral mucosal wound healing impairment via upregulation of interleukin-10. Int J Oral Sci. 2023 11;15(1):56. doi: 10.1038/s41368-023-00263-y. (Q1，IF=14.9，共同通讯）
[6]Yang Y, Li Q, Qiao Q, Zhao N, Huang H, Zhou Y, Guo C, Guo Y. Bacterial distribution and inflammatory cytokines associated with oral cancer with and without jawbone invasion-a pilot study. Clin Oral Investig. 2023;27(12):7285-7293. doi: 10.1007/s00784-023-05319-1（Q2，IF=3.4,通讯作者）
[7]卢汉,张建运,杨榕,徐乐,李庆祥,郭玉兴*,郭传瑸*. 下颌牙龈鳞状细胞癌患者预后的影响因素[J]. 北京大学学报（医学版）, 2023, 55(4): 702-707.(共同通讯)
[8]Zhao N, Li QX, Wang YF, Qiao Q, Huang HY, Guo CB, Guo YX. Anti-angiogenic drug aggravates the degree of anti-resorptive drug-based medication-related osteonecrosis of the jaw by impairing the proliferation and migration function of gingival fibroblasts. BMC Oral Health. 2023 May 27;23(1):330.(IF=3.75,Q1,共同通讯)
[9]郭玉兴,张建运,王佃灿,郭传瑸.药物相关颌骨骨坏死的病理特点及临床治疗策略.北京大学学报(医学版): 2022，54(6),1190–1195.https://doi.org/10.19723/j.issn.1671-167X.2022.06.022
[10]Hongyuan Huang, Ning Zhao, Qingxiang Li, Qiao Qiao, Jianya Zhang, Chuanbin Guo, Yuxing Guo, The Therapeutic Effectiveness Using Fluores cence-Guided Surgery for MRONJ, BioMed Research International, vol. 2022, Article ID 1650790. https://doi.org/10.1155/2022/1650790 (IF=3.25,Q3,共同通讯)
[11] Qiao Q, Xu L, Li Q, et al. Bone morphogenetic protein receptor 1α promotes osteolytic lesion of oral squamous cell carcinoma by SHH-dependent osteoclastogenesis. Cancer Sci. 2022;00:1–13. doi:10.1111/cas.15330. (IF=6.52,Q2,共同通讯作者)
[12] 郭玉兴, 赵宁, 王佃灿, 王洋, 郭传瑸. 以带蒂颊脂垫为基础的双层软组织封闭技术修复药物相关颌骨坏死手术后上颌骨缺损的临床应用. 华西口腔医学杂志[J], 2022, 40(1): 61-67 doi:10.7518/hxkq.2022.01.009
[13] Pu Y, Li Q, Wang Y, Xu L, Qiao Q, Guo Y, Guo C. pERK-mediated IL8 secretion can enhance the migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells. BMC Cancer. 2021;21(1):1283. doi: 10.1186/s12885-021-09025-7. (IF=4.62,Q2,共同通讯作者)
[14] Rong Yang, Han Lu, Yang Wang, Xin Peng, Chi Mao, Zhiqiang Yi, Yuxing Guo, Chuanbin Guo, CT-MRI Image Fusion-Based Computer-Assisted Navigation Management of Communicative Tumors Involved the Infratemporal-Middle Cranial Fossa, J Neurol Surg B 2021;82(suppl S3):e321–e329 （IF=1.42,Q4,通讯作者）
[15] Li Q, Xu L, Li Y, Yang R, Qiao Q, Wang Y, Wang L, Guo Y, Guo C. P2RY14 is a Potential Biomarker of Tumor Microenvironment Immunomodulation and Favorable Prognosis in Patients with Head and Neck Cancer. Frontiers in Genetics. 2021;12:1190.（IF=4.77,Q1,共同通讯作者）
[16] 杨榕,李庆祥,王逸飞,周闻,王雯,郭传瑸,刘浩,郭玉兴. 碘液浸染在Micro-CT下识别小鼠颅底-颞下区肿瘤组织中的应用[J]. 北京大学学报（医学版）, 2021, 53(3): 598-601.（共同通讯作者）
[17] 郭玉兴, 王佃灿, 刘筱菁, 等. 翻瓣联合骨管技术拔牙方案在药物相关性颌骨坏死潜在风险患者中的应用初探[J]. 中华口腔医学杂志, 2021, 56(5): 452-457.
[18] 杨光,王洋,张建雅,毛驰,张雷,刘睿,郭玉兴.改良胸大肌肌皮瓣与传统胸大肌肌皮瓣修复头颈大型缺损的疗效比较[J].中华老年口腔医学杂志,2021,19(02):85-89.（通讯作者）
[19] Qingxiang Li, Yinfei Pu, Han Lu, Ning Zhao, Yifei, Wang, Yuxing Guo and Chuanbin Guo. Porphyromonas Treponema and Mogibacterium promote IL8 IFN TNF based pro inflammation in patients with medication related osteonecrosis of the jaw. Journal of Oral Microbiology, 2021, 13:1, 1851112. （IF=5.83,Q2,共同通讯作者）
[20] Li Q, Wang Y, Xu L, Wang L, Guo Y, Guo C. High level of CD10 expression is associated with poor overall survival in patients with head and neck cancer. Int J Oral Maxillofac Surg. 2021 Jul;50(7):857-864.（IF=2.99,Q2,共同通讯作者）
[21] Y. Wang, Q. Li, L. Xu, J. Chen, Y. Pu, L. Wang, H. Sun, Y. Guo and C. Guo, Cancer stemness of CD10-positive cells regulated by Hedgehog pathway promotes the resistance to cisplatin in oral squamous cell carcinoma. Oral Dis. 2021;27(6):1403-1411 https://DOI:10.1111/odi.13673 （IF=4.07,Q1,共同通讯作者）
[22] Guo Y, Guo C. Enhancement of bone perfusion through cortical perforations to improve healing of medication-related osteonecrosis of the jaw: a retrospective study. Int J Oral Maxillofac Surg. 2021 Jun;50(6):740-745.(IF=2.99,Q2，第一作者)
[23] Li Q-X, Yang R, Wang Y-F, Sun H-F, Wang H-B, Liu H, Guo Y-X, Guo CB, MR imaging as a precise technique to evaluate skull-base tumor volume: comparison of CT, MR imaging and FDG PET from murine and clinical data, Journal of Cranio-Maxillofacial Surgery, 2020 Jan;48(1):105-110.（IF=3.19,Q2,共同通讯作者）
[24] 杨榕，李庆祥，毛驰，彭歆，王洋，郭玉兴，郭传瑸. 多模态影像融合技术与颅底I颞下区肿瘤的诊断和治疗[J]. 北京大学学报（医学版）, 2019,48(1):46-50.（共同通讯作者）
[25] Yuxing Guo, Yuan Yuan, Ling Wu, et al. BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair. Bone Research (2018) 6:30 ; https://doi.org/10.1038/s41413-018-0031-x(IF=13.36,Q1,第一作者)