擅长

擅长牙槽外科、口腔颌面部肿瘤(涎腺肿瘤、口腔癌、颌骨囊肿)、颌面组织缺损修复、药物相关性颌骨骨髓炎(MRONJ)的诊断和治疗(超过80例药物相关骨髓炎的手术治疗经验和超过30例该类风险患者拔牙经验,手术成功率超过85%);并微创进行各种种植牙技术(拔牙位点保存,植骨,上颌窦提升等)及复杂牙、阻生齿拔除,同期牙源性颌骨小囊肿和根尖手术治疗。

Dr. Guo is good at surgical treatment of maxillofacial tumors like salivary gland tumors or oral cancers, and medication-related osteonecrosis of the jaw and extraction of impacted teeth and teeth implantation.

简介

郭玉兴,男,河北唐山人,九三学社社员。现为北京大学口腔医院口腔颌面外科副主任医师、副教授、硕士研究生导师,口腔颌面外科毕业后教育秘书。毕业于北京大学口腔医学院,获口腔颌面外科专业博士学位。2016年至2018年于美国南加州大学牙学院进行博士后培训,专注间充质干细胞和破骨细胞间的相互作用机制研究。
多年从事牙槽外科、口腔颌面肿瘤、颌面组织缺损修复和药物相关性颌骨骨髓炎(唑来膦酸、天晴依泰、择泰、博宁、安罗替尼、卡博替尼、地舒单抗)的临床与基础研究。

Yuxing Guo, MD is a graduate of Peking University School of Stomotology, where he also attended his postgraduate studies, where graduated Hebei Medical University School of Stomotology with a Bachelor of Dental Surgery. Dr.Guo trained at the Peking University Hospital of Stomotology in Beijing at the Department of Oral and Maxillofacial Surgery. During his residency, he was able to carry out many operations of oral and maxillofacial oncology and rehabilitation, such as oral oncology resection, neck dissection, free flaps harvest, while simultaneously completing a clinical research of navigation-guided surgery. He eventually was licensed and began his career as a maxillofacial surgeon there. Afterwards, he completed a fellowship and postdoc training at Herman Ostrow School of Dentistry of USC, Center for Craniofacial Molecular Biology, with a publication related of the interplay between mesenchymal stem cells and osteoclast.

Dr.Guo has been practicing in the Department of Oral and Maxillofacial Surgery at Peking University Hospital of Stomotology in Beijing since 2014, one of the top five oral cancer hospitals in China. His practice focuses on oral and maxillofacial oncology and rehabilitation, clinical treatment of medication-related osteonecrosis of the jaw (MRONJ), and basic research of cancer stem cells, drug resistance and bony invasion of oral squamous cell carcinoma. His research has been supported by the National Natural Science Foundation of China, Beijing Municipal Science and Technology Commission, Peking University Health Center, and Peking University Hospital of Stomatology. One of his hobbies is mentoring younger students and devotes time to running teaching and educational seminars for young students interested in the sciences and medicine. He currently has 10 English publications in maxillofacial-surgery field journals and over 10 Chinese publications. He is listed as an expert to treatment of medication-related osteonecrosis of the jaw (MRONJ) in China, currently according to therapy management dependent on MRONJ staging tailored to a patient’s individual drug-using history.

Currently, Dr.Guo holds certification from the Oral and Maxillofacial-Head and Neck Cancer Committee of the Chinese Stomatological Association as a young border member. He was also awarded by Qiu Wei Liu Oral & Maxillofacial Surgery Development Foundation, and Science Technology Improvement Award of Science Research Achievement Award in Higher Education Institution of China for his contributions to navigation-guided surgery developments in the field of skull base tumors.

社会任职

中华口腔医学会口腔颌面-头颈肿瘤专委会青年委员
中国医疗保健国际交流促进会颅底外科分会委员/副秘书长
中国抗癌协会国际医疗交流专委会委员
北京癌症防治学会头颈部黑色素瘤专委会委员
北京口腔医学会口腔颌面外科专委会委员
《Cell Proliferation》审稿人
《中国生物化学与分子生物学报》审稿人

获奖荣誉

入选北京大学口腔医院第一/第二梯队科研人才培养计划
2018年获邱蔚六口腔颌面外科发展基金“希望奖”
北京口腔医学年会口腔外科病例报告比赛一等奖
2019年获高等学校科学研究科学技术进步二等奖(第三完成人)

科研成果

迄今以第一作者或通讯作者发表论文30余篇(其中SCI15篇,总影响因子40)。
主持国自然基金1项,北京首都特色临床研究项目1项,北京市自然科学基金面上项目1项,北京大学校/院项目3项。
[1] 郭玉兴,郭传瑸. Frey综合征的预防和治疗研究进展[J]. 现代口腔医学杂志, 2010,24(2):149-151, 95.
[2] 郭玉兴,郭传殡. 增强CT三维重建在颞下咽旁间隙肿瘤中的应用[J]. 北京大学学报(医学版),2011,43(1):148~150.
[3] Guo Y X, Guo C B. Relation between a first branchial cleft anomaly and the facial nerve[J]. Br J Oral Maxillofac Surg, 2012,50(3):259-263.
[4] 郭玉兴,郭传瑸,俞光岩,等. 影响颞下咽旁间隙恶性肿瘤预后的因素分析[J]. 中华神经外科杂志,2012,28(8):775~779.
[5] Jiao J, Guo Y, Jin S, et al. A method of conservative management of dislocated mandible condyle into the middle cranial fossa: Report of a case[J]. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2013,25(1):35-38.(并列第一)
[6] 郭玉兴,彭歆,刘筱菁,等. 导航技术在颅底-颞下区肿瘤手术中的应用[J]. 中华口腔医学杂志,2013,48(11):645~647.
[7] 郭玉兴,郭传瑸. 经口入路机器人手术在咽旁颞下区肿瘤外科中的应用进展[J]. 中华耳鼻咽喉头颈外科杂志, 2014,49(1):83-85.
[8] Guo Y X, Guo C B. Maxillary-fronto-temporal approach for removal of recurrent malignant infratemporal fossa tumors: Anatomical and clinical study [J]. J CraniomaxillofacSurg, 2014 Apr;42(3):206-12.
[9] Guo Y, Guo C, Zhang L, et al. Extracapsular dissection of the parapharyngeal space for a pleomorphic adenoma: a 10-year review[J]. Br J Oral MaxillofacSurg, 2014,52(6):557~562.
[10] 郭玉兴,王佃灿,安金刚,等. 二膦酸盐颌骨骨髓炎24例临床特点分析[J]. 中华口腔医学杂志, 2014,49(9):517-520.
[11] Guo Y X, Sun Z P, Liu X J, et al. Surgical safety distances in the infratemporal fossa: three-dimensional measurement study[J]. Int J Oral Maxillofac Surg, 2015,44(5):555-561.
[12] 郭玉兴,郭睿,张雷,等. 上颌-额-颞入路在颞下窝肿瘤手术中的临床应用[J]. 中国耳鼻咽喉颅底外科杂志, 2015(01):31-34.
[13] 郭玉兴,王佃灿,王洋,等. 血管化腓骨瓣修复二膦酸盐颌骨骨坏死导致的下颌骨缺损:病例报告及文献复习[J]. 中国口腔颌面外科杂志, 2015,13(5):474-477.
[14] 郭玉兴,王佃灿,王洋,等. 二膦酸盐药物治疗乳腺癌骨转移发生颌骨坏死的临床特点[J]. 北京大学学报(医学版), 2016,48(1):46-50.
[15] 郭玉兴,郭传瑸.二膦酸盐相关颌骨骨坏死临床治疗研究进展[J].中国实用口腔科杂志,2016,(3):178-181
[16] Guo, Y., Wang, D., Wang, Y., Peng, X., and Guo, C. Imaging features of medicine-related osteonecrosis of the jaws: comparison between panoramic radiography and computed tomography. Oral surgery, oral medicine, oral pathology and oral radiology, 2016, 122, e69-76
[17] Guo, Y. X., Misra, G., Guo, C. B., and An, J. G. (2016) Reconstruction of a mandibular defect after bisphosphonate-related osteonecrosis of the jaw. The British journal of oral & maxillofacial surgery 2016,54 (8), 962-964
[18] Yuxing Guo, Chi Mao. The Use of Submental Island Flap for Total Lower Lip Reconstruction: A Case Report[J]. Facial plastic surgery,2016,32(2), 238-239.
[19] 郭玉兴,郭传瑸,俞光岩. 关于药物治疗骨转移癌发生颌骨骨坏死的若干热点问题[J].现代口腔医学杂志, 2016, 30(4), 247-250.
[20]孟沛琦,郭玉兴.双侧上颌骨二膦酸盐颌骨坏死1例报道[J].北京大学学报(医学版),2017,(6):1098-1102
[21] Yuxing Guo, Yuan Yuan, Ling Wu, et al. BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair. Bone Research (2018) 6:30 ; https://doi.org/10.1038/s41413-018-0031-x
[22] 杨榕,李庆祥,毛驰,彭歆,王洋,郭玉兴,郭传瑸. 多模态影像融合技术与颅底I颞下区肿瘤的诊断和治疗[J]. 北京大学学报(医学版), 2019,48(1):46-50.
[23] Li Q-X, Yang R, Wang Y-F, Sun H-F, Wang H-B, Liu H, Guo Y-X, Guo CB, MR imaging as a precise technique to evaluate skull-base tumor volume: comparison of CT, MR imaging and FDG PET from murine and clinical data, Journal of Cranio-Maxillofacial Surgery, 2020 Jan;48(1):105-110.(共同通讯作者)
[24] 郭玉兴,郭传瑸.口腔癌肿瘤干细胞研究进展[J].北京口腔医学,2020,28(1):46-49.
[25] Guo Y, Guo C. Enhancement of bone perfusion through cortical perforations to improve healing of medication-related osteonecrosis of the jaw: a retrospective study. Int J Oral Maxillofac Surg. 2021 Jun;50(6):740-745.
[26] Y. Wang, Q. Li, L. Xu, J. Chen, Y. Pu, L. Wang, H. Sun, Y. Guo and C. Guo, Cancer stemness of CD10-positive cells regulated by Hedgehog pathway promotes the resistance to cisplatin in oral squamous cell carcinoma, Oral Disease, 2020, https://DOI:10.1111/odi.13673 (共同通讯作者)
[27] Li Q, Wang Y, Xu L, Wang L, Guo Y, Guo C. High level of CD10 expression is associated with poor overall survival in patients with head and neck cancer. Int J Oral Maxillofac Surg. 2021 Jul;50(7):857-864.(共同通讯作者)
[28] Qingxiang Li, Yinfei Pu, Han Lu, Ning Zhao, Yifei, Wang, Yuxing Guo and Chuanbin Guo. Porphyromonas Treponema and Mogibacterium promote IL8 IFN TNF based pro inflammation in patients with medication related osteonecrosis of the jaw. Journal of Oral Microbiology, 2021, 13:1, 1851112. (共同通讯作者)
[29] 杨光,王洋,张建雅,毛驰,张雷,刘睿,郭玉兴.改良胸大肌肌皮瓣与传统胸大肌肌皮瓣修复头颈大型缺损的疗效比较[J].中华老年口腔医学杂志,2021,19(02):85-89.
[30] 郭玉兴, 王佃灿, 刘筱菁, 等. 翻瓣联合骨管技术拔牙方案在药物相关性颌骨坏死潜在风险患者中的应用初探[J]. 中华口腔医学杂志, 2021, 56(5): 452-457.
[31] 杨榕,李庆祥,王逸飞,周闻,王雯,郭传瑸,刘浩,郭玉兴. 碘液浸染在Micro-CT下识别小鼠颅底-颞下区肿瘤组织中的应用[J]. 北京大学学报(医学版), 2021, 53(3): 598-601.
[32] Li Q, Xu L, Li Y, Yang R, Qiao Q, Wang Y, Wang L, Guo Y, Guo C. P2RY14 is a Potential Biomarker of Tumor Microenvironment Immunomodulation and Favorable Prognosis in Patients with Head and Neck Cancer. Frontiers in Genetics. 2021;12:1190.(共同通讯作者)
[33] Rong Yang, Han Lu, Yang Wang, Xin Peng, Chi Mao, Zhiqiang Yi, Yuxing Guo, Chuanbin Guo, CT-MRI Image Fusion-Based Computer-Assisted Navigation Management of Communicative Tumors Involved the Infratemporal-Middle Cranial Fossa, J Neurol Surg B 2021;82(suppl S3):e321–e329 (通讯作者)

进修经历

2016年4月-2018年3月美国南加州大学Herman Ostrow牙学院CCMB实验室 博士后辅导医生:柴洋教授

工作经历

2020年8月-至今北京大学口腔医院 口腔颌面外科副教授/硕士研究生导师
2019年8月-2020年8月北京大学口腔医院 口腔颌面外科副主任医师
2014年8月-2019年7月北京大学口腔医院 口腔颌面外科主治医师
2013年8月-2014年7月北京大学口腔医院 口腔颌面外科住院医师

教育经历

博士北京大学口腔医学院口腔颌面外科专业
*基本信息来自医院官网或医院内公示信息或医生本人提供
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郭玉兴

郭玉兴

副主任医师 副教授

郭玉兴的出诊时间

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  • 北大口腔医院 颌面外科
  • 北京微尔特口腔门诊部 颌面外科
  • 09/30 周四 下午

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  • 10/01 周五 下午

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  • 10/07 周四 下午

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  • 09/29 周三 下午

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