小细胞肺癌NCCN指南2018v1证据块

NCCN EVIDENCE BLOCKS CATEGORIES AND DEFINITIONS
NCCN证据块分类和定义

E = Efficacy of Regimen/Agent
E=方案/药物的疗效

S = Safety of Regimen/Agent
S=方案/药物的安全性

Q = Quality of Evidence
Q=证据的质量

C = Consistency of Evidence
C=证据的一致性

A = Affordability of Regimen/Agent
A=方案/药物的承受能力

Efficacy of Regimen/Agent
方案/药物的疗效

5 Highly effective: Cure likely and often provides long-term survival advantage
5高度有效:可能治愈并常常带来长期生存优势

4 Very effective: Cure unlikely but sometimes provides long-term survival advantage
4非常有效：不太可能治愈，但有时带来长期生存优势

3 Moderately effective: Modest impact on survival, but often provides control of disease
3中等有效：适度影响生存，但往往能控制病情

2 Minimally effective: No, or unknown impact on survival, but sometimes provides control of disease
2极少有效：不能或不清楚是否影响生存，但有时能控制病情

1 Palliative: Provides symptomatic benefit only
1姑息性：只能改善症状

Safety of Regimen/Agent
方案/药物的安全性

5 Usually no meaningful toxicity: Uncommon or minimal toxicities; no interference with activities of daily living (ADLs)
5通常没有有意义的毒性：毒性罕见或极小；不妨碍日常生活活动（ADLs）

4 Occasionally toxic: Rare significant toxicities or low-grade toxicities only; little interference with ADLs
4偶尔有毒：罕见严重毒性或仅有低度毒性；几乎不妨碍ADLs

3 Mildly toxic: Mild toxicity that interferes with ADLs
3轻度毒性：轻度毒性，妨碍ADLs

2 Moderately toxic: Significant toxicities often occur but life threatening/fatal toxicity is uncommon; interference with ADLs is frequent
2中度毒性：时常发生严重毒性，但危及生命/致命的毒性不常见；时常妨碍ADLs

1 Highly toxic: Significant toxicities or life threatening/fatal toxicity occurs often; interference with ADLs is usual and severe
1高度毒性：经常发生严重毒性或危及生命/致命的毒性；常见且严重妨碍ADLs

Note: For significant chronic or long-term toxicities, score decreased by 1
注意：对于显著的慢性或远期毒性，评分下降1

Quality of Evidence
证据的质量

5 High quality: Multiple well-designed randomized trials and/or meta-analyses
5高质量：多个精心设计的随机试验和/或meta分析

4 Good quality: One or more well-designed randomized trials
4质量好：一个或多个精心设计的随机试验

3 Average quality: Low quality randomized trial(s) or well-designed non-randomized trial(s)
3普通质量：一项或多项低质量的随机试验或精心设计的非随机试验

2 Low quality: Case reports or extensive clinical experience
2低质量：病例报告或丰富的临床经验

1 Poor quality: Little or no evidence
1质量差：几乎或根本没有证据

Consistency of Evidence
证据的一致性

5 Highly consistent: Multiple trials with similar outcomes
5高度一致：多个试验具有相似结果

4 Mainly consistent: Multiple trials with some variability in outcome
4基本一致：多个试验具有部分差异

3 May be consistent: Few trials or only trials with few patients, whether randomized or not, with some variability in outcome
3多半一致：很少的试验或只有少数患者的试验，不管随机与否，结果有部分差异

2 Inconsistent: Meaningful differences in direction of outcome between quality trials
2不一致：质量试验之间的结果趋势差异有意义

1 Anecdotal evidence only: Evidence in humans based upon anecdotal experience
1只有坊间证据：基于坊间经验的人类证据

Affordability of Regimen/Agent (includes drug cost, supportive care, infusions, toxicity monitoring, management of toxicity)
方案/药物的支付能力（包括药费、支持治疗、输液、毒性监测、毒性管理）

5 Very inexpensive
5很便宜

4 Inexpensive
4便宜

3 Moderately expensive
3中等昂贵

2 Expensive
2昂贵

1 Very expensive
1很昂贵